Basic Information
| Drug ID | DDPD00408 |
|
| Drug Name | Loxapine | |
| Molecular Weight | 327.808 | |
| Molecular Formula | C18H18ClN3O | |
| CAS Number | 1977-10-2 | |
| SMILES | CN1CCN(CC1)C1=NC2=CC=CC=C2OC2=C1C=C(Cl)C=C2 | |
| External Links | ||
| DRUGBANK | DB00408 | |
| T3DB | T3D2779 | |
| PubChem Compound | 3964 | |
| PDR | 1794 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.6 | - | 3.6 | - | DRUGBANK |
| Melting Point | 110.0 | ℃ | 109-111 | ℃ | U.S. Patents 3,412,193; 3,546,226. |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 33.0 | % | 33.0 | % | IM,intramuscular injection; Male, men; | DRUGBANK |
| Half-life | 4.0 | h | 4 | h | PO, oral; | DRUGBANK |
| Toxicity LD50 | 65.0 | mg/kg | 65.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 65.0 | mg/kg | 65.0 | mg/kg | PO, oral; mouse; | T3DB |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adolescents | 15.0 | mg/day | 15 | mg/day | PO, oral | Loxapine | loxapine | PDR |
| Max dose for adults | 100.0 | mg/day | 100 | mg/day | PO, oral | Loxapine | loxapine | PDR |
| Max dose for adults | 250.0 | mg/day | 250 | mg/day | PO, oral | Loxapine | loxapine | PDR |
| Max dose for adults | 10.0 | mg/day | 10 | mg/day | inhalation, IH | Loxapine | loxapine | PDR |
| Max dose for geriatric | 100.0 | mg/day | 100 | mg/day | PO, oral | Loxapine | loxapine | PDR |
| Max dose for geriatric | 250.0 | mg/day | 250 | mg/day | PO, oral | Loxapine | loxapine | PDR |
| Max dose for geriatric | 10.0 | mg/day | 10 | mg/day | inhalation, IH | Loxapine | loxapine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1