Basic Information
| Drug ID | DDPD00401 |
|
| Drug Name | Nisoldipine | |
| Molecular Weight | 388.4144 | |
| Molecular Formula | C20H24N2O6 | |
| CAS Number | 63675-72-9 | |
| SMILES | COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC=C1[N+]([O-])=O)C(=O)OCC(C)C | |
| External Links | ||
| DRUGBANK | DB00401 | |
| PubChem Compound | 4499 | |
| PDR | 1042 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.26 | - | 3.26 | - | MASUMOTO,K ET AL. (1995) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 5.0 | % | 5.0 | % | DRUGBANK | |
| Clearance | 0.90 | L/h/kg | 15 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 5.5 | L/kg | 5.5 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 9.5 | h | 7-12 | h | DRUGBANK | Half-life | 11.0 | h | 11 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 99.0 | % | 99 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 34.0 | mg/day | 34 | mg/day | PO, oral | Sular | nisoldipine | PDR |
| Max dose for elderly | 34.0 | mg/day | 34 | mg/day | PO, oral | Sular | nisoldipine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1