Basic Information
| Drug ID | DDPD00400 |
|
| Drug Name | Griseofulvin | |
| Molecular Weight | 352.766 | |
| Molecular Formula | C17H17ClO6 | |
| CAS Number | 126-07-8 | |
| SMILES | COC1=CC(OC)=C(Cl)C2=C1C(=O)[C@]1(O2)[C@H](C)CC(=O)C=C1OC | |
| External Links | ||
| DRUGBANK | DB00400 | |
| T3DB | T3D4696 | |
| PubChem Compound | 441140 | |
| PDR | 2447 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Caco-2 Permeability | -4.44 | - | -4.44 | - | ADME Research, USCD |
| Log P | 2.18 | - | 2.18 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 220.0 | ℃ | 220 | ℃ | PhysProp |
| Water Solubility | 8.64 | mg/L | 8.64 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| Log S | -4.61 | - | -4.61 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 47.5 | % | 25-70 | % | PO, oral; | DRUGBANK |
| Half-life | 15.0 | h | 9-21 | h | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 15.0 | mg/kg/day | 15 | mg/kg/day | PO, oral | Griseofulvin Oral Suspension | griseofulvin | PDR |
| Max dose for children | 750.0 | mg/day | 750 | mg/day | PO, oral | Griseofulvin Oral Suspension | griseofulvin | PDR |
| Max dose for children | 20.0 | mg/kg/day | 20 | mg/kg/day | PO, oral | Griseofulvin Oral Suspension | griseofulvin | PDR |
| Max dose for children | 1000.0 | mg/day | 1 | g/day | PO, oral | Griseofulvin Oral Suspension | griseofulvin | PDR |
| Max dose for adolescents | 750.0 | mg/day | 750 | mg/day | PO, oral | Griseofulvin Oral Suspension | griseofulvin | PDR |
| Max dose for adolescents | 1000.0 | mg/day | 1 | g/day | PO, oral | Griseofulvin Oral Suspension | griseofulvin | PDR |
| Max dose for adults | 750.0 | mg/day | 750 | mg/day | PO, oral | Griseofulvin Oral Suspension | griseofulvin | PDR |
| Max dose for adults | 1000.0 | mg/day | 1 | g/day | PO, oral | Griseofulvin Oral Suspension | griseofulvin | PDR |
| Max dose for geriatric | 750.0 | mg/day | 750 | mg/day | PO, oral | Griseofulvin Oral Suspension | griseofulvin | PDR |
| Max dose for geriatric | 1000.0 | mg/day | 1 | g/day | PO, oral | Griseofulvin Oral Suspension | griseofulvin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1