Basic Information
Experimental Physicochemical Property
Not Available
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 788.0 | ng.h/ml | 788±181 | ng.h/ml | intravenous injection, IV; | DRUGBANK | AUC | 917.0 | ng.h/ml | 917±226 | ng.h/ml | intravenous injection, IV; | DRUGBANK |
| C Max | 370.0 | ng/ml | 370±78.5 | ng/ml | intravenous injection, IV; | DRUGBANK | C Max | 471.0 | ng/ml | 471±76.1 | ng/ml | intravenous injection, IV; | DRUGBANK |
| T Max | 0.32 | h | 0.317±0.014 | h | intravenous injection, IV; | DRUGBANK | T Max | 0.37 | h | 0.368±0.005 | h | intravenous injection, IV; | DRUGBANK |
| Metabolic | 0 | % | 0 | % | DRUGBANK | |
| Clearance | 3.7 | L/h | 3.7±2.0 | L/h | Renal clearance; | DRUGBANK | Clearance | 0.13 | L/h/kg | 2.2 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.60 | L/kg | 0.6 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 146.0 | h | 146 | h | elimination half-life; | DRUGBANK | Half-life | 11.0 | h | 11 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 39.0 | % | 39±16 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 38.0 | % | 23-53 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 4.0 | mg/dose | 4 | mg/dose | intravenous infusion, iv in drop | Reclast | zoledronic acid | PDR |
| Max dose for adults | 5.0 | mg/dose | 5 | mg/dose | intravenous infusion, iv in drop | Reclast | zoledronic acid | PDR |
| Max dose for geriatric | 4.0 | mg/dose | 4 | mg/dose | intravenous infusion, iv in drop | Reclast | zoledronic acid | PDR |
| Max dose for geriatric | 5.0 | mg/dose | 5 | mg/dose | intravenous infusion, iv in drop | Reclast | zoledronic acid | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1