Basic Information
| Drug ID | DDPD00398 |
|
| Drug Name | Sorafenib | |
| Molecular Weight | 464.825 | |
| Molecular Formula | C21H16ClF3N4O3 | |
| CAS Number | 284461-73-0 | |
| SMILES | CNC(=O)C1=NC=CC(OC2=CC=C(NC(=O)NC3=CC(=C(Cl)C=C3)C(F)(F)F)C=C2)=C1 | |
| External Links | ||
| DRUGBANK | DB00398 | |
| T3DB | T3D3533 | |
| PubChem Compound | 216239 | |
| PDR | 95 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.8 | - | 3.8 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| T Max | 3.0 | h | 3 | h | PO, oral; | DRUGBANK |
| Metabolic | 12.5 | % | 9-16 | % | DRUGBANK | |
| Half-life | 36.5 | h | 25-48 | h | DRUGBANK | |
| Eliminate Route | 77.0 | % | 77 | % | Faeces excretion; PO, oral; | DRUGBANK | Eliminate Route | 19.0 | % | 19 | % | Urinary excretion; PO, oral; | DRUGBANK |
| Protein Binding | 99.5 | % | 99.5 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 800.0 | mg/day | 800 | mg/day | PO, oral | Nexavar | sorafenib | PDR |
| Max dose for elderly | 800.0 | mg/day | 800 | mg/day | PO, oral | Nexavar | sorafenib | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1