Basic Information
| Drug ID | DDPD00396 |
|
| Drug Name | Progesterone | |
| Molecular Weight | 314.4617 | |
| Molecular Formula | C21H30O2 | |
| CAS Number | 57-83-0 | |
| SMILES | [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C | |
| External Links | ||
| DRUGBANK | DB00396 | |
| PubChem Compound | 5994 | |
| PDR | 2090 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.87 | - | 3.87 | - | http://www.hmdb.ca/metabolites/HMDB0001830 |
| Boiling Point | 394.13 | ℃ | 394.13 | ℃ | https://www.chemicalbook.com/ChemicalProductProperty_US_CB4224484.aspx |
| Melting Point | 130.0 | ℃ | 128-132 | ℃ | https://www.chemicalbook.com/ChemicalProductProperty_US_CB4224484.aspx |
| Water Solubility | 1000.0 | mg/L | <0.1 | g/100ml | https://www.chemicalbook.com/ChemicalProductProperty_US_CB4224484.aspx |
| pKa | 18.92 | - | 18.92,-4.8 | - | http://www.hmdb.ca/metabolites/HMDB0001830 | pKa | -4.8 | - | 18.92,-4.8 | - | DRUGBANK |
| Log S | -4.43 | - | -4.43 | - | http://www.hmdb.ca/metabolites/HMDB0001830 |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| C Max | 7.0 | ng/ml | 7.0 | ng/ml | IM,intramuscular injection; | DRUGBANK | C Max | 28.0 | ng/ml | 28.0 | ng/ml | IM,intramuscular injection; | DRUGBANK | C Max | 50.0 | ng/ml | 50.0 | ng/ml | IM,intramuscular injection; | DRUGBANK |
| T Max | 3.0 | h | 3 | h | Capsule, PO, Oral; | DRUGBANK | T Max | 8.0 | h | 8 | h | IM,intramuscular injection; | DRUGBANK |
| Clearance | 106.0 | L/h | 106±15 | L/h | IM,intramuscular injection; | DRUGBANK | Clearance | 1367.0 | L/h | 1367±348 | L/h | Vaginal Administration; | DRUGBANK |
| Half-life | 37.5 | h | ~25-50 | h | distribution half-life; gel; | DRUGBANK | Half-life | 0.21 | h | 5-20 | min | elimination half-life; gel; | DRUGBANK | Half-life | 0.0833 | h | ~5 | min | elimination half-life; PO, oral; | DRUGBANK |
| Toxicity LD50 | 327.0 | mg/kg | 327.0 | mg/kg | Intraperitoneal, IP; Rattus, Rat; | DRUGBANK |
| Protein Binding | 97.5 | % | 96-99 | % | DRUGBANK | Protein Binding | 52.0 | % | 50-54 | % | DRUGBANK |
Maximum Dosage
Not Available
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1