Basic Information
| Drug ID | DDPD00393 |
|
| Drug Name | Nimodipine | |
| Molecular Weight | 418.4403 | |
| Molecular Formula | C21H26N2O7 | |
| CAS Number | 66085-59-4 | |
| SMILES | COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OC(C)C | |
| External Links | ||
| DRUGBANK | DB00393 | |
| PubChem Compound | 4497 | |
| PDR | 1392 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 3.05 | - | 3.05 | - | MASUMOTO,K ET AL. (1995) |
| Melting Point | 125.0 | ℃ | 125 | ℃ | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 16.5 | % | 3-30 | % | PO, oral; | DRUGBANK | Bioavailability | 100.0 | % | 100 | % | intravenous injection, IV; | DRUGBANK |
| T Max | 1.0 | h | 1 | h | PO, oral; | DRUGBANK |
| Clearance | 0.90 | L/h/kg | 15 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.1 | L/kg | 1.1 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 5.4 | h | 1.7-9 | h | DRUGBANK | Half-life | 1.3 | h | 1.3 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 1.0 | % | <1 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 95.0 | % | 95 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 30.0 | mg/day | 30 | mg/day | PO, oral | Nimodipine | nimodipine | PDR |
| Max dose for children | 48.0 | mg/day | 48 | mg/day | PO, oral | Nimodipine | nimodipine | PDR |
| Max dose for children | 60.0 | mg/day | 60 | mg/day | PO, oral | Nimodipine | nimodipine | PDR |
| Max dose for adolescents | 30.0 | mg/day | 30 | mg/day | PO, oral | Nimodipine | nimodipine | PDR |
| Max dose for adolescents | 48.0 | mg/day | 48 | mg/day | PO, oral | Nimodipine | nimodipine | PDR |
| Max dose for adolescents | 60.0 | mg/day | 60 | mg/day | PO, oral | Nimodipine | nimodipine | PDR |
| Max dose for adults | 360.0 | mg/day | 360 | mg/day | PO, oral | Nimodipine | nimodipine | PDR |
| Max dose for elderly | 360.0 | mg/day | 360 | mg/day | PO, oral | Nimodipine | nimodipine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1