Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00388 ...
Drug Name Phenylephrine
Molecular Weight 167.205
Molecular Formula C9H13NO2
CAS Number 59-42-7
SMILES CNC[C@H](O)C1=CC(O)=CC=C1
External Links
DRUGBANK DB00388
PubChem Compound 6041
PDR 3539
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -0.31 - -0.31 - HANSCH,C ET AL. (1995)
Melting Point 142.5 ℃ 140-145 ℃ DRUGBANK
pKa 8.97 - 8.97 - SANGSTER (1994)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 38.0 % 38.0 % PO, oral; DRUGBANK
Clearance 126.0 L/h 2100.0 ml/min Average clearance; DRUGBANK
Volume of Distribution 340.0 L 340.0 L DRUGBANK
Half-life 0.0833 h 5 min effective half-life; intravenous injection, IV; DRUGBANK
Half-life 2.5 h 2.5 h elimination half-life; intravenous injection, IV; DRUGBANK
Eliminate Route 86.0 % 86 % Urinary excretion; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 1.0 drop/dose 1 drop/dose ophthalmic administration Vazculep phenylephrine hydrochloride PDR
Max dose for infants 60.0 mg/day 60 mg/day PO, oral Vazculep phenylephrine hydrochloride PDR
Max dose for infants 3.0 sprays/drops/nostriL 3 sprays/drops/nostriL nasal spray Vazculep phenylephrine hydrochloride PDR
Max dose for infants 1.0 drop/dose 1 drop/dose ophthalmic administration Vazculep phenylephrine hydrochloride PDR
Max dose for infants 4.0 appLication/day 4 appLication/day skin ointment Vazculep phenylephrine hydrochloride PDR
Max dose for infants 4.0 suppositories/day 4 suppositories/day Rectal Administration Vazculep phenylephrine hydrochloride PDR
Max dose for infants 30.0 mg/day 30 mg/day PO, oral Vazculep phenylephrine hydrochloride PDR
Max dose for infants 3.0 sprays/drops/nostriL 3 sprays/drops/nostriL nasal spray Vazculep phenylephrine hydrochloride PDR
Max dose for infants 1.0 drop/dose 1 drop/dose skin ointment Vazculep phenylephrine hydrochloride PDR
Max dose for infants 15.0 mg/day 15 mg/day PO, oral Vazculep phenylephrine hydrochloride PDR
Max dose for infants 3.0 drop/nostriL 3 drop/nostriL nasal spray Vazculep phenylephrine hydrochloride PDR
Max dose for infants 1.0 drop/dose 1 drop/dose ophthalmic administration Vazculep phenylephrine hydrochloride PDR
Max dose for infants 15.0 mg/day 15 mg/day PO, oral Vazculep phenylephrine hydrochloride PDR
Max dose for infants 3.0 drop/nostriL 3 drop/nostriL nasal spray Vazculep phenylephrine hydrochloride PDR
Max dose for infants 1.0 drop/dose 1 drop/dose ophthalmic administration Vazculep phenylephrine hydrochloride PDR
Max dose for infants 1.0 drop/dose 1 drop/dose ophthalmic administration Vazculep phenylephrine hydrochloride PDR
Max dose for children 60.0 mg/day 60 mg/day PO, oral Vazculep phenylephrine hydrochloride PDR
Max dose for children 3.0 sprays/drops/nostril 3 sprays/drops/nostril nasal spray Vazculep phenylephrine hydrochloride PDR
Max dose for children 1.0 drop/dose 1 drop/dose ophthalmic administration Vazculep phenylephrine hydrochloride PDR
Max dose for children 4.0 application/day 4 application/day skin ointment Vazculep phenylephrine hydrochloride PDR
Max dose for children 4.0 suppositories/day 4 suppositories/day Rectal Administration Vazculep phenylephrine hydrochloride PDR
Max dose for adolescents 60.0 mg/day 60 mg/day PO, oral Vazculep phenylephrine hydrochloride PDR
Max dose for adolescents 3.0 sprays/drops/nostril 3 sprays/drops/nostril nasal spray Vazculep phenylephrine hydrochloride PDR
Max dose for adolescents 1.0 drop/dose 1 drop/dose ophthalmic administration Vazculep phenylephrine hydrochloride PDR
Max dose for adolescents 4.0 application/day 4 application/day skin ointment Vazculep phenylephrine hydrochloride PDR
Max dose for adolescents 4.0 suppositories/day 4 suppositories/day Rectal Administration Vazculep phenylephrine hydrochloride PDR
Max dose for geriatric 60.0 mg/day 60 mg/day PO, oral Vazculep phenylephrine hydrochloride PDR
Max dose for geriatric 3.0 sprays/drops/nostril 3 sprays/drops/nostril nasal spray Vazculep phenylephrine hydrochloride PDR
Max dose for geriatric 1.0 drop/dose 1 drop/dose ophthalmic administration Vazculep phenylephrine hydrochloride PDR
Max dose for geriatric 4.0 application/day 4 application/day skin ointment Vazculep phenylephrine hydrochloride PDR
Max dose for geriatric 4.0 suppositories/day 4 suppositories/day Rectal Administration Vazculep phenylephrine hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1