Basic Information

Drug ID DDPD00382 ...
Drug Name Tacrine
Molecular Weight 198.2637
Molecular Formula C13H14N2
CAS Number 321-64-2
SMILES NC1=C2CCCCC2=NC2=CC=CC=C12
External Links
DRUGBANK DB00382
T3DB T3D2772
PubChem Compound 1935
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.71 - 2.71 - HANSCH,C ET AL. (1995)
Melting Point 183.5 183.5 PhysProp
Water Solubility 217.0 mg/L 217 mg/L DRUGBANK
pKa 9.95 - 9.95 - PERRIN,DD (1972)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 17.0 % 17.0 % DRUGBANK
Clearance 3.4 L/h/kg 56 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 349.0 L 349±193 L DRUGBANK
Volume of Distribution 11.0 L/kg 11 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 3.0 h 2-4 h DRUGBANK
Half-life 3.3 h 3.3 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 40.0 mg/kg 40.0 mg/kg Oral single dose; Rattus, Rat; DRUGBANK
Toxicity MRHD 160.0 mg/day 160.0 mg/day DRUGBANK
Toxicity Lethal Dose 40.0 mg/kg 40.0 mg/kg Oral single dose; Rattus, Rat; T3DB
Protein Binding 55.0 % 55 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1