Basic Information
| Drug ID | DDPD00379 |
|
| Drug Name | Mexiletine | |
| Molecular Weight | 179.2588 | |
| Molecular Formula | C11H17NO | |
| CAS Number | 31828-71-4 | |
| SMILES | CC(N)COC1=C(C)C=CC=C1C | |
| External Links | ||
| DRUGBANK | DB00379 | |
| PubChem Compound | 4178 | |
| PDR | 659 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.15 | - | 2.15 | - | MANNHOLD,R ET AL. (1990) |
| Melting Point | 204.0 | ℃ | 203-205 | ℃ | PhysProp |
| Water Solubility | 8250.0 | mg/L | 8.25 | mg/ml | DRUGBANK |
| pKa | 9.2 | - | 9.2 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 90.0 | % | 90.0 | % | PO, oral; | DRUGBANK |
| Metabolic | 85.0 | % | 85 | % | Liver metabolism; | DRUGBANK |
| Clearance | 0.50 | L/h/kg | 8.3 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 6.0 | L/lg | 5-7.0 | L/lg | DRUGBANK | Volume of Distribution | 5.9 | L/kg | 5.9 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 11.0 | h | 10-12 | h | DRUGBANK | Half-life | 9.9 | h | 9.9 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 10.0 | % | ~10 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 55.0 | % | 50-60 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 15.0 | mg/kg/day | 15 | mg/kg/day | PO, oral | Mexiletine Hydrochloride | mexiletine hydrochloride | PDR |
| Max dose for adolescents | 15.0 | mg/kg/day | 15 | mg/kg/day | PO, oral | Mexiletine Hydrochloride | mexiletine hydrochloride | PDR |
| Max dose for adolescents | 1200.0 | mg/day | 1200 | mg/day | PO, oral | Mexiletine Hydrochloride | mexiletine hydrochloride | PDR |
| Max dose for adults | 1200.0 | mg/day | 1200 | mg/day | PO, oral | Mexiletine Hydrochloride | mexiletine hydrochloride | PDR |
| Max dose for elderly | 1200.0 | mg/day | 1200 | mg/day | PO, oral | Mexiletine Hydrochloride | mexiletine hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1