Basic Information
| Drug ID | DDPD00374 |
|
| Drug Name | Treprostinil | |
| Molecular Weight | 390.5131 | |
| Molecular Formula | C23H34O5 | |
| CAS Number | 81846-19-7 | |
| SMILES | [H][C@]12C[C@@H](O)[C@H](CC[C@@H](O)CCCCC)[C@@]1([H])CC1=C(C2)C(OCC(O)=O)=CC=C1 | |
| External Links | ||
| DRUGBANK | DB00374 | |
| PubChem Compound | 6918140 | |
| PDR | 1004 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.1 | - | 4.1 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 100.0 | % | 100.0 | % | subcutaneous injection, SC; | DRUGBANK |
| Bioavailability | 100.0 | % | 100.0 | % | subcutaneous injection, SC; | DRUGBANK |
| Clearance | 0.64 | L/h/kg | 10.7 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.20 | L/kg | 0.2 | L/kg | DRUGBANK | Volume of Distribution | 0.23 | L/kg | 0.23 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.0 | h | ~2-4 | h | elimination half-life; | DRUGBANK | Half-life | 0.57 | h | 34 | min | elimination half-life; intravenous infusion, IV in drop; | DRUGBANK | Half-life | 1.4 | h | 85 | min | elimination half-life; subcutaneous infusion; | DRUGBANK | Half-life | 0.82 | h | 0.82 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 91.0 | % | ~91 | % | plasma proteins; human, homo sapiens; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adolescents | 0.00029 | mg/kg/day | 290 | ng/kg/min | parenteral administration | Remodulin | treprostinil | PDR |
| Max dose for adolescents | 8.6e-05 | mg/kg/day | 86 | ng/kg/min | intravenous injection, IV | Remodulin | treprostinil | PDR |
| Max dose for adults | 0.4176 | mg/kg/day | 290 | ng/kg/min | parenteral administration | Remodulin | treprostinil | PDR |
| Max dose for adults | 9.0 | breaths | 9 | breaths | inhalation, IH | Remodulin | treprostinil | PDR |
| Max dose for adults | 21.0 | mg | 21 | mg | Tablet,PO，oral | Remodulin | treprostinil | PDR |
| Max dose for geriatric | 0.004176 | mg/kg/day | 290 | ng/kg/min | parenteral administration | Remodulin | treprostinil | PDR |
| Max dose for geriatric | 9.0 | breaths | 9 | breaths | inhalation, IH | Remodulin | treprostinil | PDR |
| Max dose for geriatric | 21.0 | mg | 21 | mg | Tablet,PO，oral | Remodulin | treprostinil | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1