Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00373 ...
Drug Name Timolol
Molecular Weight 316.42
Molecular Formula C13H24N4O3S
CAS Number 26839-75-8
SMILES [H][C@](O)(CNC(C)(C)C)COC1=NSN=C1N1CCOCC1
External Links
DRUGBANK DB00373
PubChem Compound 33624
PDR 1322
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Caco-2 Permeability 159.0 - 159.0 - https://journals.sagepub.com/doi/pdf/10.1177/1087057107308892
Log P 1.8 - 1.8 - http://secure.healthlinks.net.au/content/apo/index_pi_apo.cfm?product=txpdorti
Boiling Point 100.0 ℃ >100 ℃ https://imgcdn.mckesson.com/CumulusWeb/Click_and_learn/SDS_9AKORN_TIMOLOL_MALEATE_DRP_OPHTH_5ML.pdf
Melting Point 202.5 ℃ 202-203 ℃ https://www.chemicalbook.com/ChemicalProductProperty_US_CB3711352.aspx
pKa 9.2 - 9.2 - http://secure.healthlinks.net.au/content/apo/index_pi_apo.cfm?product=txpdorti

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 4.8 ng.h/ml 4.78 ng.h/ml ophthalmic administration; DRUGBANK
AUC 6.5 ng.h/ml 6.46 ng.h/ml intravenous injection, IV; DRUGBANK
Bioavailability 78.0 % 78.0±24.5 % ophthalmic administration; different study; DRUGBANK
Bioavailability 60.0 % 60.0 % ophthalmic administration; different study; DRUGBANK
Bioavailability 61.0 % 61±6 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 1.1 ng/ml 1.14 ng/ml ophthalmic administration; DRUGBANK
C Max 61.0 ng/ml 61±39 ng/ml PO, oral; extensive metabolizers, EM; The Pharmacological Basis of Therapeutics
C Max 114.0 ng/ml 114±21 ng/ml PO, oral; poor metabolizers, PM; The Pharmacological Basis of Therapeutics
T Max 0.25 h 0.25 h ophthalmic administration; DRUGBANK
T Max 1.2 h 1.2±0.4 h PO, oral; extensive metabolizers, EM; The Pharmacological Basis of Therapeutics
T Max 1.8 h 1.8±0.8 h PO, oral; poor metabolizers, PM; The Pharmacological Basis of Therapeutics
Metabolic 90.0 % 90 % Liver metabolism; DRUGBANK
Clearance 33.4 L/h 557±61 ml/min Plasma clearance; normal,healthy; DRUGBANK
Clearance 45.1 L/h 751.5±90.6 ml/min Total clearance; normal,healthy; DRUGBANK
Clearance 5.8 L/h 97.2±10.1 ml/min Renal clearance; normal,healthy; DRUGBANK
Clearance 0.46 L/h/kg 7.7±1.2 ml/min/kg hydrolysis; The Pharmacological Basis of Therapeutics
Clearance 0.51 L/h/kg 8.5 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 1.5 L/kg 1.3-1.7 L/kg DRUGBANK
Volume of Distribution 1.7 L/kg 1.7±0.2 L/kg hydrolysis; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.5 L/kg 1.5 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.9 h 2.9±0.3 h normal,healthy; DRUGBANK
Half-life 2.7 h 2.7±0.5 h CYP2D6 genetic polymorphisms; The Pharmacological Basis of Therapeutics
Half-life 7.5 h 7.5±3.0 h poor metabolizers, PM; hydrolysis; PO, oral; The Pharmacological Basis of Therapeutics
Half-life 3.7 h 3.7±1.7 h extensive metabolizers, EM; PO, oral; The Pharmacological Basis of Therapeutics
Half-life 2.2 h 2.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 1028.0 mg/kg 1028.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 1137.0 mg/kg 1137.0 mg/kg PO, oral; mouse; DRUGBANK
Eliminate Route 8.0 % 8±4 % Urinary excretion; PO, oral; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 10.0 % ~10 % plasma proteins; DRUGBANK
Protein Binding 10.0 % <10 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for children 1.0 drop/day 1 drop/day ophthalmic administration bid Betimol timolol PDR
Max dose for children 1.0 drop/day 1 drop/day ophthalmic administration Betimol timolol PDR
Max dose for adolescents 1.0 drop/day 1 drop/day ophthalmic administration bid Betimol timolol PDR
Max dose for adolescents 1.0 drop/day 1 drop/day ophthalmic administration Betimol timolol PDR
Max dose for adults 60.0 mg/day 60 mg/day PO, oral Betimol timolol PDR
Max dose for adults 30.0 mg/day 30 mg/day PO, oral Betimol timolol PDR
Max dose for adults 20.0 mg/day 20 mg/day PO, oral Betimol timolol PDR
Max dose for adults 1.0 drop/day 1 drop/day ophthalmic administration bid Betimol timolol PDR
Max dose for adults 1.0 drop/day 1 drop/day ophthalmic administration Betimol timolol PDR
Max dose for geriatric 60.0 mg/day 60 mg/day PO, oral Betimol timolol PDR
Max dose for geriatric 30.0 mg/day 30 mg/day PO, oral Betimol timolol PDR
Max dose for geriatric 20.0 mg/day 20 mg/day PO, oral Betimol timolol PDR
Max dose for geriatric 1.0 drop/day 1 drop/day ophthalmic administration bid Betimol timolol PDR
Max dose for geriatric 1.0 drop/day 1 drop/day ophthalmic administration Betimol timolol PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1