Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00369 ...
Drug Name Cidofovir
Molecular Weight 279.187
Molecular Formula C8H14N3O6P
CAS Number 113852-37-2
SMILES NC1=NC(=O)N(C[C@@H](CO)OCP(O)(O)=O)C=C1
External Links
DRUGBANK DB00369
PubChem Compound 60613
PDR 1760
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -3.9 - -3.9 - DRUGBANK
Melting Point 480.0 ℃ 480 ℃ DRUGBANK
Water Solubility 170000.0 mg/L 170 mg/ml DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 100.0 % 100.0 % DRUGBANK
Bioavailability 98.0 % 98±10 % subcutaneous injection, SC; The Pharmacological Basis of Therapeutics
Bioavailability 5.0 % <5 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 19600.0 ng/ml 19.6±7.2 mcg/ml The Pharmacological Basis of Therapeutics
Clearance 6.2 L/h/m2 179±23.1 ml/min/1.73m2 DRUGBANK
Clearance 0.13 L/h/kg 2.1±0.6 ml/min/kg AIDS,HIV; positive for CMV; RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.15 L/h/kg 2.5 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.54 L/kg 537±126 mL/kg DRUGBANK
Volume of Distribution 0.41 L/kg 410±102 mL/kg DRUGBANK
Volume of Distribution 0.36 L/kg 0.36±0.13 L/kg AIDS,HIV; positive for CMV; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.49 L/kg 0.49 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.8 h 2.4-3.2 h DRUGBANK
Half-life 2.3 h 2.3±0.5 h AIDS,HIV; positive for CMV; patients; RD, renal impairment, Renal disease，including uremia ↑ ; The Pharmacological Basis of Therapeutics
Half-life 2.6 h 2.6 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 70.1 % 70.1±21.4 % Urinary excretion; AIDS,HIV; positive for CMV; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 6.0 % 6 % DRUGBANK
Protein Binding 6.0 % <6 % AIDS,HIV; positive for CMV; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 0.714285714285714 mg/kg/day 5 mg/kg/week intravenous injection, IV Vistide cidofovir PDR
Max dose for elderly 0.714285714285714 mg/kg/day 5 mg/kg/week intravenous injection, IV Vistide cidofovir PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1