Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00367 ...
Drug Name Levonorgestrel
Molecular Weight 312.4458
Molecular Formula C21H28O2
CAS Number 797-63-7
SMILES [H][C@@]12CC[C@@](O)(C#C)[C@@]1(CC)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H]
External Links
DRUGBANK DB00367
T3DB T3D4749
PubChem Compound 13109
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.8 - 3.8 - http://www.hmdb.ca/metabolites/HMDB0014511
Boiling Point 459.1 ℃ 459.1 ℃ https://www.lookchem.com/Levonorgestrel/
Melting Point 240.0 ℃ 240 ℃ https://www.scbt.com/scbt/product/levonorgestrel-797-63-7
Water Solubility 5.8 mg/L 0.0058 g/L http://www.t3db.ca/toxins/T3D4749
pKa 17.91 - 17.91,-1.5 - http://www.hmdb.ca/metabolites/HMDB0014511
pKa -1.5 - 17.91,-1.5 - http://www.hmdb.ca/metabolites/HMDB0014511
Log S -4.7 - -4.7 - http://www.hmdb.ca/metabolites/HMDB0014511

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 360.1 ng.h/ml 360.1 ng.h/ml PO, oral; DRUGBANK
AUC 202.7 ng.h/ml 197.28-208.1 ng.h/ml PO, oral; Obesity; Obesity ↓ ; DRUGBANK
Bioavailability 100.0 % ~100 % PO, oral; DRUGBANK
C Max 16.2 ng/ml 16.2 ng/ml PO, oral; DRUGBANK
C Max 10.5 ng/ml 10.5 ng/ml PO, oral; Obesity; Obesity ↓ ; DRUGBANK
T Max 60.0 h 2-3 day subdermal implant; DRUGBANK
T Max 1.0 h 1 h Oral single dose; DRUGBANK
T Max 2.0 h 2 h PO, oral; DRUGBANK
T Max 2.5 h 2.5 h PO, oral; Obesity; Obesity ↓ ; DRUGBANK
Clearance 4.8 L/h 4.8 L/h normal,healthy;  Female, women; DRUGBANK
Clearance 8.1 L/h 7.70-8.51 L/h Obesity; patients; DRUGBANK
Clearance 7.1 L/h 7.06 L/h Average clearance; DRUGBANK
Clearance 0.11 L/h/kg 1.8 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 162.2 L 162.2 L Steady state volume of distribution; normal,healthy; DRUGBANK
Volume of Distribution 435.6 L 404.7-466.4 L Steady state volume of distribution; Obesity; DRUGBANK
Volume of Distribution 260.0 L 260.0 L Average volume of distribution; DRUGBANK
Volume of Distribution 1.8 L/kg 1.8 L/kg Apparent volume of distribution; DRUGBANK
Volume of Distribution 1.5 L/kg 1.5 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 40.0 h 20-60 h elimination half-life; DRUGBANK
Half-life 29.7 h 29.7 h elimination half-life;  Female, women; DRUGBANK
Half-life 43.7 h 41.0-46.4 h elimination half-life; BMI over;  Female, women; DRUGBANK
Half-life 24.4 h 24.4 h elimination half-life; patients; DRUGBANK
Half-life 9.4 h 9.4 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 5000.0 mg/kg >5000 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 5000.0 mg/kg >5000 mg/kg PO, oral; Rattus, Rat; T3DB
Eliminate Route 45.0 % ~45 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 32.0 % ~32 % Faeces excretion; PO, oral; DRUGBANK
Protein Binding 98.3 % 97.5-99 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1