Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00363 ...
Drug Name Clozapine
Molecular Weight 326.823
Molecular Formula C18H19ClN4
CAS Number 5786-21-0
SMILES CN1CCN(CC1)C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12
External Links
DRUGBANK DB00363
T3DB T3D2764
PubChem Compound 2818
PDR 1695
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.23 - 3.23 - HANSCH,C ET AL. (1995)
Melting Point 183.5 ℃ 183-184 ℃ PhysProp
Water Solubility 11.8 mg/L 11.8 mg/L DRUGBANK
pKa 7.5 - 7.5 - EL TAYAR,N ET AL. (1985)

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Absorption 100.0 % ~100 % DRUGBANK
Bioavailability 55.0 % 55±12 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 546.0 ng/ml 546±307 ng/ml Tablet, PO, oral; adults; The Pharmacological Basis of Therapeutics
T Max 1.9 h 1.9±0.8 h Tablet, PO, oral; adults; The Pharmacological Basis of Therapeutics
Clearance 0.37 L/h/kg 6.1±1.6 ml/min/kg The Pharmacological Basis of Therapeutics
Clearance 0.15 L/h/kg 2.5 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 5.4 L/kg 5.4±3.5 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 1.6 L/kg 1.6 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 8.0 h 8(4-12) h DRUGBANK
Half-life 12.0 h 12±4 h The Pharmacological Basis of Therapeutics
Half-life 10.0 h 10 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 50.0 % ~50 % Urinary excretion; DRUGBANK
Eliminate Route 30.0 % ~30 % Faeces excretion; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 97.0 % 97 % DRUGBANK
Protein Binding 95.0 % >95 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 300.0 mg/day 300 mg/day PO, oral Clozaril clozapine PDR
Max dose for adolescents 300.0 mg/day 300 mg/day PO, oral Clozaril clozapine PDR
Max dose for adults 900.0 mg/day 900 mg/day PO, oral Clozaril clozapine PDR
Max dose for geriatric 900.0 mg/day 900 mg/day PO, oral Clozaril clozapine PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1