Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00361 ...
Drug Name Vinorelbine
Molecular Weight 778.947
Molecular Formula C45H54N4O8
CAS Number 71486-22-1
SMILES [H][C@@]12N(C)C3=CC(OC)=C(C=C3[C@@]11CCN3CC=C[C@](CC)([C@@]13[H])[C@@]([H])(OC(C)=O)[C@]2(O)C(=O)OC)[C@]1(C[C@@]2([H])CN(CC(CC)=C2)CC2=C1NC1=CC=CC=C21)C(=O)OC
External Links
DRUGBANK DB00361
PubChem Compound 44424639
PDR 2360
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 4.0 - 4.0 - DRUGBANK
Melting Point 182.0 ℃ 181-183 ℃ MSDS
Water Solubility 10000.0 mg/L 10 mg/ml MSDS

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 27.0 % 27±12 % Liquid; The Pharmacological Basis of Therapeutics
C Max 114.0 ng/ml 114±43 ng/ml The Pharmacological Basis of Therapeutics
C Max 1130.0 ng/ml 1130±636 ng/ml The Pharmacological Basis of Therapeutics
T Max 2.0 h 2 h DRUGBANK
T Max 1.5 h 1.5±1.0 h The Pharmacological Basis of Therapeutics
Clearance 0.78 L/kg 0.29-1.26 L/kg Plasma clearance; patients; DRUGBANK
Clearance 1.3 L/h/kg 21±7 ml/min/kg hepatopathy，LD ↓ ; The Pharmacological Basis of Therapeutics
Clearance 1.2 L/h/kg 20 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 32.8 L/kg 25.4-40.1 L/kg Steady state volume of distribution; DRUGBANK
Volume of Distribution 76.0 L/kg 76±41 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 23.0 L/kg 23 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 35.7 h 27.7-43.6 h terminal half-life; DRUGBANK
Half-life 42.0 h 42±21 h elimination half-life; The Pharmacological Basis of Therapeutics
Half-life 26.0 h 26 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 18.0 % ~18 % Urinary excretion; intravenous injection, IV; DRUGBANK
Eliminate Route 46.0 % ~46 % Faeces excretion; intravenous injection, IV; DRUGBANK
Eliminate Route 20.0 % <20 % Urinary excretion; intravenous injection, IV; Unchanged drug; DRUGBANK
Eliminate Route 45.0 % 30-60 % Faeces excretion; intravenous injection, IV; Unchanged drug; DRUGBANK
Eliminate Route 11.0 % 11 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 85.0 % 80-90 % DRUGBANK
Protein Binding 87.0 % 87(80-91) % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 30.0 mg/m2 30 mg/m2 intravenous injection, IV Navelbine vinorelbine tartrate PDR
Max dose for elderly 30.0 mg/m2 30 mg/m2 intravenous injection, IV Navelbine vinorelbine tartrate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1