Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00358 ...
Drug Name Mefloquine
Molecular Weight 378.3122
Molecular Formula C17H16F6N2O
CAS Number 53230-10-7
SMILES OC(C1CCCCN1)C1=CC(=NC2=C1C=CC=C2C(F)(F)F)C(F)(F)F
External Links
DRUGBANK DB00358
PubChem Compound 4046
PDR 1437
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.9 - 3.9 - DRUGBANK
Water Solubility 5000.0 mg/L 5000 mg/L DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
C Max 910.0 ng/ml 800-1020 ng/ml Oral single dose; The Pharmacological Basis of Therapeutics
C Max 420.0 ng/ml 420±141 ng/ml Oral multiple dose; The Pharmacological Basis of Therapeutics
T Max 13.3 h 7-19.6 h Oral single dose; The Pharmacological Basis of Therapeutics
T Max 12.0 h 12±8 h Oral multiple dose; The Pharmacological Basis of Therapeutics
Clearance 1.8 L/h 30.0 ml/min DRUGBANK
Clearance 0.0258 L/h/kg 0.43±0.14 ml/min/kg apparent clearance; Children → ;Preg, pregnant ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 20.0 L/kg 20.0 L/kg normal,healthy; adults; DRUGBANK
Volume of Distribution 19.0 L/kg 19±6 L/kg Apparent volume of distribution; The Pharmacological Basis of Therapeutics
Half-life 504.0 h 2-4 week DRUGBANK
Half-life 480.0 h 20±4 day Preg, pregnant ↓ ;Children → ; The Pharmacological Basis of Therapeutics
Toxicity LD50 880.0 mg/kg 880.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 9.0 % ~9 % Urinary excretion; at steady state; Unchanged drug; DRUGBANK
Eliminate Route 1.0 % <1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 98.0 % 98 % DRUGBANK
Protein Binding 98.2 % 98.2 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for infants 5.0 mg/kg/dose 5 mg/kg/dose PO, oral qw Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for infants 22.5 mg/kg 22.5 mg/kg PO, oral Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for children 1250.0 mg 1250 mg PO, oral Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for children 250.0 mg 250 mg PO, oral qw Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for children 187.5 mg 187.5 mg PO, oral qw Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for children 125.0 mg 125 mg PO, oral qw Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for children 62.5 mg 62.5 mg PO, oral qw Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for children 22.5 mg/kg 22.5 mg/kg PO, oral Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for children 22.5 mg/kg 22.5 mg/kg PO, oral Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for children 22.5 mg/kg 22.5 mg/kg PO, oral Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for children 22.5 mg/kg 22.5 mg/kg PO, oral Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for adolescents 1250.0 mg 1250 mg PO, oral Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for adolescents 250.0 mg 250 mg PO, oral qw Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for adolescents 187.5 mg 187.5 mg PO, oral qw Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for adolescents 22.5 mg/kg 22.5 mg/kg PO, oral Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for adolescents 22.5 mg/kg 22.5 mg/kg PO, oral Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for adults 1250.0 mg 1250 mg PO, oral Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for adults 250.0 mg 250 mg PO, oral qw Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for geriatric 1250.0 mg 1250 mg PO, oral Mefloquine Hydrochloride mefloquine hydrochloride PDR
Max dose for geriatric 250.0 mg 250 mg PO, oral qw Mefloquine Hydrochloride mefloquine hydrochloride PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1