Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00357 ...
Drug Name Aminoglutethimide
Molecular Weight 232.2783
Molecular Formula C13H16N2O2
CAS Number 125-84-8
SMILES CCC1(CCC(=O)NC1=O)C1=CC=C(N)C=C1
External Links
DRUGBANK DB00357
T3DB T3D4806
PubChem Compound 2145
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.3 - 1.3 - DRUGBANK
Melting Point 224.0 ℃ 223-225 ℃ Hoffmann, K.and Urech, E.; U.S. Patent 2848,455; August 19,1958; assigned to Ciba Pharmaceutical Products, Inc.

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Absorption 100.0 % 100.0 % PO, oral; DRUGBANK
Metabolic 44.0 % 34-54 % Urinary excretion; DRUGBANK
Half-life 12.5 h 12.5±1.6 h DRUGBANK
Toxicity LD50 1800.0 mg/kg 1800.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 100.0 mg/kg >100 mg/kg PO, oral; dog; DRUGBANK
Toxicity LD50 156.0 mg/kg 156.0 mg/kg intravenous injection, IV; Rattus, Rat; DRUGBANK
Toxicity LD50 100.0 mg/kg >100 mg/kg intravenous injection, IV; dog; DRUGBANK
Toxicity LD50 1800.0 mg/kg 1800.0 mg/kg PO, oral; Rattus, Rat; T3DB
Toxicity LD50 100.0 mg/kg >100 mg/kg PO, oral; dog; T3DB
Toxicity LD50 156.0 mg/kg 156.0 mg/kg intravenous injection, IV; Rattus, Rat; T3DB
Toxicity LD50 100.0 mg/kg >100 mg/kg intravenous injection, IV; dog; T3DB
Eliminate Route 44.0 % 34-54 % Urinary excretion; Oral single dose; Unchanged drug; DRUGBANK
Protein Binding 23.0 % 21-25 % DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1