Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00355 ...
Drug Name Aztreonam
Molecular Weight 435.433
Molecular Formula C13H17N5O8S2
CAS Number 78110-38-0
SMILES C[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(=O)O)\C2=CSC([NH3+])=N2)C(=O)N1S([O-])(=O)=O
External Links
DRUGBANK DB00355
PubChem Compound 9568617
PDR 160
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Not Available

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 1.0 % <1 % PO, oral; DRUGBANK
Absorption 100.0 % 100.0 % IM,intramuscular injection; DRUGBANK
Metabolic 16.0 % 16 % Liver metabolism; Inactive metabolite; DRUGBANK
Clearance 5460.0 L/h 91.0 L/min normal,healthy; DRUGBANK
Clearance 0.0900 L/h/kg 1.5 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 12.6 L 12.6 L DRUGBANK
Volume of Distribution 0.18 L/kg 0.18 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.7 h 1.7(1.5-2.0） h elimination half-life; normal renal function; dose → ; DRUGBANK
Half-life 5.4 h 4.7-6 h Elderly; patients; DRUGBANK
Half-life 2.1 h 2.1 h RD, renal impairment, Renal disease，including uremia; patients; DRUGBANK
Half-life 1.5 h 1.5 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Protein Binding 56.0 % 56 % dose → ; DRUGBANK
Protein Binding 39.5 % 36-43 % renal insufficiency; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 120.0 mg/kg/day 120 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for neonates 90.0 mg/kg/day 90 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for neonates 90.0 mg/kg/day 90 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for neonates 60.0 mg/kg/day 60 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for infants 120.0 mg/kg/day 120 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for infants 300.0 mg/kg/day 300 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for infants 120.0 mg/kg/day 120 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for infants 300.0 mg/kg/day 300 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for children 120.0 mg/kg/day 120 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for children 8000.0 mg/day 8 g/day intravenous injection, IV Cayston aztreonam PDR
Max dose for children 300.0 mg/kg/day 300 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for children 12000.0 mg/day 12 g/day intravenous injection, IV Cayston aztreonam PDR
Max dose for children 120.0 mg/kg/day 120 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for children 300.0 mg/kg/day 300 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for children 225.0 mg/day 225 mg/day skin/dermal Cayston aztreonam PDR
Max dose for adolescents 225.0 mg/day 225 mg/day skin/dermal Cayston aztreonam PDR
Max dose for adolescents 120.0 mg/kg/day 120 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for adolescents 8000.0 mg/day 8 g/day intravenous injection, IV Cayston aztreonam PDR
Max dose for adolescents 300.0 mg/kg/day 300 mg/kg/day intravenous injection, IV Cayston aztreonam PDR
Max dose for adolescents 12000.0 mg/day 12 g/day intravenous injection, IV Cayston aztreonam PDR
Max dose for adults 225.0 mg/day 225 mg/day skin/dermal Cayston aztreonam PDR
Max dose for adults 8000.0 mg/day 8 g/day intravenous injection, IV;IM,intramuscular injection; Cayston aztreonam PDR
Max dose for adults 12000.0 mg/day 12 g/day intravenous injection, IV Cayston aztreonam PDR
Max dose for geriatric 225.0 mg/day 225 mg/day skin/dermal Cayston aztreonam PDR
Max dose for geriatric 8000.0 mg/day 8 g/day intravenous injection, IV;IM,intramuscular injection; Cayston aztreonam PDR
Max dose for geriatric 12000.0 mg/day 12 g/day intravenous injection, IV Cayston aztreonam PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1