Basic Information
| Drug ID | DDPD00353 |
|
| Drug Name | Methylergometrine | |
| Molecular Weight | 339.4314 | |
| Molecular Formula | C20H25N3O2 | |
| CAS Number | 113-42-8 | |
| SMILES | [H][C@@]12CC3=CNC4=CC=CC(=C34)C1=C[C@H](CN2C)C(=O)N[C@@H](CC)CO | |
| External Links | ||
| DRUGBANK | DB00353 | |
| T3DB | T3D3686 | |
| PubChem Compound | 8226 | |
| PDR | 3895 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.2 | - | 1.2 | - | DRUGBANK |
| Melting Point | 172.0 | ℃ | 172 | ℃ | PhysProp |
| Water Solubility | 25000.0 | mg/L | 25 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 60.0 | % | 60.0 | % | PO, oral; | DRUGBANK | Bioavailability | 78.0 | % | 78.0 | % | IM,intramuscular injection; | DRUGBANK |
| Clearance | 0.43 | L/h/kg | 7.18 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 56.1 | L | 56.1 | L | DRUGBANK | Volume of Distribution | 0.96 | L/kg | 0.96 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 3.4 | h | 3.39 | h | DRUGBANK | Half-life | 1.9 | h | 1.85 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 0.8 | mg/day | 0.8 | mg/day | PO, oral; up to 7 days | Methylergonovine Maleate Injection | methylergonovine maleate | PDR |
| Max dose for elderly | 0.8 | mg/day | 0.8 | mg/day | PO, oral; up to 7 days | Methylergonovine Maleate Injection | methylergonovine maleate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1