Basic Information
| Drug ID | DDPD00350 |
|
| Drug Name | Minoxidil | |
| Molecular Weight | 209.2483 | |
| Molecular Formula | C9H15N5O | |
| CAS Number | 38304-91-5 | |
| SMILES | NC1=CC(=NC(N)=[N+]1[O-])N1CCCCC1 | |
| External Links | ||
| DRUGBANK | DB00350 | |
| PubChem Compound | 4201 | |
| PDR | 774 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.24 | - | 1.24 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 248.0 | ℃ | 248 | ℃ | PhysProp |
| Water Solubility | 2200.0 | mg/L | 2200 | mg/L | MERCK INDEX 1996) |
| pKa | 4.61 | - | 4.61 | - | MERCK INDEX (2001) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 90.0 | % | 90.0 | % | PO, oral; Male, men; | DRUGBANK |
| Metabolic | 90.0 | % | 90 | % | DRUGBANK | |
| Clearance | 0.69 | L/h/kg | 11.5 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.90 | L/kg | 0.9 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 4.2 | h | 4.2 | h | DRUGBANK | Half-life | 1.5 | h | 1.5 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 2406.5 | mg/kg | 1321-3492 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 2552.0 | mg/kg | 2456-2648 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Protein Binding | 0 | % | 0 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 50.0 | mg/day | 50 | mg/day | PO, oral | Minoxidil | minoxidil | PDR |
| Max dose for adolescents | 100.0 | mg/day | 100 | mg/day | PO, oral | Minoxidil | minoxidil | PDR |
| Max dose for adults | 100.0 | mg/day | 100 | mg/day | PO, oral | Minoxidil | minoxidil | PDR |
| Max dose for adults | 2.0 | ml/day | 2 | ml/day | skin/dermal | Minoxidil | minoxidil | PDR |
| Max dose for adults | 1.0 | capfuL/day | 1 | capfuL/day | skin/dermal | Minoxidil | minoxidil | PDR |
| Max dose for elderly | 100.0 | mg/day | 100 | mg/day | PO, oral | Minoxidil | minoxidil | PDR |
| Max dose for elderly | 2.0 | ml/day | 2 | ml/day | skin/dermal | Minoxidil | minoxidil | PDR |
| Max dose for elderly | 1.0 | capful/day | 1 | capful/day | skin/dermal | Minoxidil | minoxidil | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1