Basic Information
| Drug ID | DDPD00348 |
|
| Drug Name | Nitisinone | |
| Molecular Weight | 329.2281 | |
| Molecular Formula | C14H10F3NO5 | |
| CAS Number | 104206-65-7 | |
| SMILES | [O-][N+](=O)C1=C(C=CC(=C1)C(F)(F)F)C(=O)C1C(=O)CCCC1=O | |
| External Links | ||
| DRUGBANK | DB00348 | |
| PubChem Compound | 115355 | |
| PDR | 1629 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.6 | - | 1.6 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Half-life | 54.0 | h | ~54 | h | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 2.0 | mg/kg/day | 2 | mg/kg/day | PO, oral | Orfadin | nitisinone | PDR |
| Max dose for children | 2.0 | mg/kg/day | 2 | mg/kg/day | PO, oral | Orfadin | nitisinone | PDR |
| Max dose for adolescents | 2.0 | mg/kg/day | 2 | mg/kg/day | PO, oral | Orfadin | nitisinone | PDR |
| Max dose for adults | 2.0 | mg/kg/day | 2 | mg/kg/day | PO, oral | Orfadin | nitisinone | PDR |
| Max dose for elderly | 2.0 | mg/kg/day | 2 | mg/kg/day | PO, oral | Orfadin | nitisinone | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1