Basic Information
| Drug ID | DDPD00346 |
|
| Drug Name | Alfuzosin | |
| Molecular Weight | 389.4488 | |
| Molecular Formula | C19H27N5O4 | |
| CAS Number | 81403-80-7 | |
| SMILES | COC1=CC2=C(C=C1OC)C(N)=NC(=N2)N(C)CCCNC(=O)C1CCCO1 | |
| External Links | ||
| DRUGBANK | DB00346 | |
| PubChem Compound | 2092 | |
| PDR | 528 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.4 | - | 1.4 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 50.0 | % | <50 | % | PO, oral; fasting; | DRUGBANK |
| Clearance | 0.35 | L/h/kg | 5.9 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 3.2 | L/kg | 3.2 | L/kg | normal,healthy; Male, men; | DRUGBANK | Volume of Distribution | 1.5 | L/kg | 1.5 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 10.0 | h | 10 | h | DRUGBANK | Half-life | 4.8 | h | 4.8 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 69.0 | % | 69 | % | Faeces excretion; PO, oral; | DRUGBANK | Eliminate Route | 24.0 | % | 24 | % | Urinary excretion; PO, oral; | DRUGBANK |
| Protein Binding | 86.0 | % | 82-90 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 10.0 | mg/day | 10 | mg/day | PO, oral | Uroxatral | alfuzosin hydrochloride | PDR |
| Max dose for geriatric | 10.0 | mg/day | 10 | mg/day | PO, oral | Uroxatral | alfuzosin hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1