Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00338 ...
Drug Name Omeprazole
Molecular Weight 345.416
Molecular Formula C17H19N3O3S
CAS Number 73590-58-6
SMILES COC1=CC2=C(C=C1)N=C(N2)S(=O)CC1=NC=C(C)C(OC)=C1C
External Links
DRUGBANK DB00338
T3DB T3D3524
PubChem Compound 4594
PDR 1123
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.23 - 2.23 - http://www.thepharmajournal.com/archives/2015/vol4issue8/PartA/4-8-12.pdf
Boiling Point 599.991 ℃ 599.991 ℃ https://www.lookchem.com/Omeprazole/
Melting Point 155.0 ℃ 155 ℃ FDA label
Water Solubility 359.0 mg/L 0.359 mg/ml http://www.thepharmajournal.com/archives/2015/vol4issue8/PartA/4-8-12.pdf
pKa 9.29 - 9.29,4.77 - https://www.chemicalbook.com/ChemicalProductProperty_US_CB8160492.aspx
pKa 4.77 - 9.29,4.77 - https://www.chemicalbook.com/ChemicalProductProperty_US_CB8160492.aspx

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 35.0 % 30-40 % DRUGBANK
T Max 2.0 h 0.5-3.5 h DRUGBANK
Clearance 33.0 L/h 500-600 ml/min normal,healthy; DRUGBANK
Clearance 15.0 L/h 250.0 ml/min Plasma clearance; Geriatric; DRUGBANK
Clearance 4.2 L/h 70.0 ml/min Plasma clearance; hepatopathy，LD; DRUGBANK
Clearance 0.50 L/h/kg 8.4 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.30 L/kg ~0.3 L/kg DRUGBANK
Volume of Distribution 0.24 L/kg 0.24 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 0.75 h 0.5-1 h normal,healthy; extended release formulation; Capsule, PO, Oral; DRUGBANK
Half-life 3.0 h ~3 h hepatopathy，LD; DRUGBANK
Half-life 0.58 h 0.58 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 4000.0 mg/kg 4000.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 2210.0 mg/kg 2210.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Protein Binding 95.0 % ~95 % plasma proteins; human, homo sapiens; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for neonates 0.7 mg/kg/day 0.7 mg/kg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for neonates 1.5 mg/kg/day 1.5 mg/kg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for infants 10.0 mg/day 10 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for infants 40.0 mg/day 40 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for infants 5.0 mg/day 5 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for infants 1.5 mg/day 1.5 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for infants 2.5 mg/day 2.5 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for infants 1.5 mg/day 1.5 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for children 20.0 mg/day 20 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for children 80.0 mg/day 80 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for children 10.0 mg/day 10 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for children 3.3 mg/kg/day 3.3 mg/kg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for children 40.0 mg/day 40 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for children 5.0 mg/day 5 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for children 3.3 mg/kg/day 3.3 mg/kg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for adolescents 40.0 mg/day 40 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for adolescents 80.0 mg/day 80 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for adults 40.0 mg/day 40 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for adults 160.0 mg/day 160 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for adults 360.0 mg/day 360 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for geriatric 40.0 mg/day 40 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for geriatric 160.0 mg/day 160 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR
Max dose for geriatric 360.0 mg/day 360 mg/day PO, oral Prilosec Delayed Release Capsules and Oral Suspension (omeprazole); (omeprazole magnesium) PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1