Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00333 ...
Drug Name Methadone
Molecular Weight 309.4452
Molecular Formula C21H27NO
CAS Number 76-99-3
SMILES CCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C1=CC=CC=C1
External Links
DRUGBANK DB00333
T3DB T3D2676
PubChem Compound 4095
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 3.93 - 3.93 - HANSCH,C ET AL. (1995)
Melting Point 235.0 ℃ 235 ℃ DRUGBANK
pKa 9.2 - 9.2 - A497

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 68.0 % 36-100 % PO, oral; DRUGBANK
Bioavailability 92.0 % 92±21 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 689.5 ng/ml 124-1255 ng/ml PO, oral; DRUGBANK
C Max 524.5 ng/ml 69-980 ng/ml PO, oral; patients; The Pharmacological Basis of Therapeutics
C Max 500.0 ng/ml 450-550 ng/ml intravenous injection, IV; patients; The Pharmacological Basis of Therapeutics
Css 332.5 ng/ml 35-630 ng/ml PO, oral; DRUGBANK
T Max 4.3 h 1-7.5 h PO, oral; DRUGBANK
T Max 3.0 h ~3 h PO, oral; patients; The Pharmacological Basis of Therapeutics
T Max 3.0 h ~3 h intravenous injection, IV; patients; The Pharmacological Basis of Therapeutics
Clearance 63.7 L/h 1.4-126 L/h DRUGBANK
Clearance 0.10 L/h/kg 1.7±0.9 ml/min/kg Children ↑ ;Burn ↑ ; The Pharmacological Basis of Therapeutics
Clearance 0.10 L/h/kg 1.7 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 329.5 L 189-470 L DRUGBANK
Volume of Distribution 3.6 L/kg 3.6±1.2 L/kg Apparent volume of distribution; The Pharmacological Basis of Therapeutics
Volume of Distribution 4.4 L/kg 4.4 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 33.0 h 7-59 h DRUGBANK
Half-life 27.0 h 27±12 h Children ↓ ;Burn ↓ ; The Pharmacological Basis of Therapeutics
Half-life 31.0 h 31 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 24.0 % 24±10 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 87.5 % 85-90 % DRUGBANK
Protein Binding 89.0 % 89±2.9 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1