Basic Information
| Drug ID | DDPD00332 |
|
| Drug Name | Ipratropium | |
| Molecular Weight | 332.463 | |
| Molecular Formula | C20H30NO3 | |
| CAS Number | 60205-81-4 | |
| SMILES | [H][C@]12CC[C@]([H])(C[C@@H](C1)OC(=O)C(CO)C1=CC=CC=C1)[N+]2(C)C(C)C | |
| External Links | ||
| DRUGBANK | DB00332 | |
| PubChem Compound | 657308 | |
| PDR | 1741 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.038 | - | 0.038 | - | Wood C. et al. 1995. J Allergy Clin Immunol. |
| Boiling Point | 230.0 | ℃ | 230 | ℃ | Brittain H. 2003. Profiles of Drug Substances. |
| Melting Point | 230.0 | ℃ | 230 | ℃ | Brittain H. 2003. Profiles of Drug Substances. |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 2.0 | % | 2.0 | % | PO, oral; inhalation, IH; | DRUGBANK |
| T Max | 1.5 | h | 1-2 | h | PO, oral; inhalation, IH; | DRUGBANK |
| Metabolic | 10.0 | % | ~10 | % | gastrointestinal tract; | DRUGBANK |
| Clearance | 138.0 | L/h | 2.3 | L/min | Average clearance; | DRUGBANK | Clearance | 54.0 | L/h | 0.9 | L/min | Renal clearance; | DRUGBANK | Clearance | 1.9 | L/h/kg | 31.4 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 4.6 | L/kg | 4.6 | L/kg | DRUGBANK | Volume of Distribution | 5.1 | L/kg | 5.1 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.6 | h | ~1.6 | h | DRUGBANK | Half-life | 1.6 | h | 1.64 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 1500.0 | mg/kg | 1500.0 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Eliminate Route | 90.0 | % | ~80-100 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 20.0 | % | <20 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 4.5 | % | 0-9 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 0.672 | mg/day | 672 | mcg/day | intranasal | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for children | 12.0 | puffs/day | 12 | puffs/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for children | 4.0 | dose/day | 4 | dose/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for children | 2.0 | mg/day | 2000 | mcg/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for children | 0.504 | mg/day | 504 | mcg/day | intranasal | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for adolescents | 0.672 | mg/day | 672 | mcg/day | intranasal | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for adolescents | 12.0 | puffs/day | 12 | puffs/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for adolescents | 4.0 | dose/day | 4 | dose/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for adolescents | 2.0 | mg/day | 2000 | mcg/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for adults | 0.672 | mg/day | 672 | mcg/day | intranasal | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for adults | 12.0 | puffs/day | 12 | puffs/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for adults | 0.204 | mg/day | 204 | mcg/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for adults | 4.0 | dose/day | 4 | dose/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for adults | 2.0 | mg/day | 2000 | mcg/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for geriatric | 0.672 | mg/day | 672 | mcg/day | intranasal | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for geriatric | 12.0 | puffs/day | 12 | puffs/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for geriatric | 0.204 | mg/day | 204 | mcg/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for geriatric | 4.0 | dose/day | 4 | dose/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
| Max dose for geriatric | 2.0 | mg/day | 2000 | mcg/day | inhalation, IH | Atrovent Nasal Spray 0.03% | ipratropium bromide | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1