Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00331 ...
Drug Name Metformin
Molecular Weight 129.1636
Molecular Formula C4H11N5
CAS Number 657-24-9
SMILES CN(C)C(=N)NC(N)=N
External Links
DRUGBANK DB00331
T3DB T3D3522
PubChem Compound 4091
PDR 1636
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P -2.6 - -2.6 - https://www.sciencedirect.com/science/article/pii/S1319016413001229
Boiling Point 224.1 ℃ 224.1 ℃ http://www.molbase.com/en/properties_1115-70-4-moldata-22670.html
Melting Point 224.5 ℃ 223-226 ℃ http://www.molbase.com/en/properties_1115-70-4-moldata-22670.html
pKa 12.4 - 12.4 - FDA label

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 55.0 % 50-60 % Tablet, PO, oral; fasting; DRUGBANK
Bioavailability 52.0 % 52±5(40-55) % PO, oral; The Pharmacological Basis of Therapeutics
C Max 1600.0 ng/ml 1.6±0.2 mcg/ml Tablet, PO, oral; The Pharmacological Basis of Therapeutics
C Max 2050.0 ng/ml 1.0-3.1 mcg/ml PO, oral; The Pharmacological Basis of Therapeutics
Css 1000.0 ng/ml <1 ug/ml PO, oral; DRUGBANK
T Max 7.0 h 7(4-8) h PO, oral; extended release formulation; DRUGBANK
T Max 1.9 h 1.9±0.4 h Tablet, PO, oral; The Pharmacological Basis of Therapeutics
T Max 2.5 h 1.5-3.5 h PO, oral; The Pharmacological Basis of Therapeutics
Tss 36.0 h 24-48 h PO, oral; DRUGBANK
Metabolic 0 % 0 % DRUGBANK
Clearance 0.49 L/h/kg 6.3-10.1 ml/min/kg Elderly ↓ ;mild renal function ↓ ;moderate renal function ↓ ;severe renal function ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.44 L/h/kg 7.4 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 654.0 L 654±358 L Apparent volume of distribution; PO, oral; DRUGBANK
Volume of Distribution 2.3 L/kg 0.9-3.94 L/kg The Pharmacological Basis of Therapeutics
Volume of Distribution 0.64 L/kg 0.64 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 6.2 h 6.2 h DRUGBANK
Half-life 17.6 h 17.6 h elimination half-life; DRUGBANK
Half-life 1.7 h 1.74±0.20(1.5-4.5) h mild renal function ↑ ;moderate renal function ↑ ;severe renal function ↑ ;Age ↑ ; The Pharmacological Basis of Therapeutics
Half-life 1.7 h 1.7 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 1000.0 mg/kg 1.0 g/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 500.0 mg/kg 500.0 mg/kg Intraperitoneal, IP; Rattus, Rat; DRUGBANK
Toxicity LD50 300.0 mg/kg 300.0 mg/kg subcutaneous injection, SC; Rattus, Rat; DRUGBANK
Toxicity LD50 1450.0 mg/kg 1450.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 420.0 mg/kg 420.0 mg/kg Intraperitoneal, IP; mouse; DRUGBANK
Toxicity LD50 225.0 mg/kg 225.0 mg/kg subcutaneous injection, SC; Rattus, Rat; DRUGBANK
Toxicity LD50 350.0 mg/kg 350.0 mg/kg PO, oral; rabbit; T3DB
Eliminate Route 90.0 % ~90 % Urinary excretion; PO, oral; DRUGBANK
Eliminate Route 99.9 % 99.9±0.5 % Urinary excretion; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 89.5 % 79-100 % Urinary excretion; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 0 % ~0 % human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 2000.0 mg/day 2000 mg/day Tablet,PO，oral;Liquid; Riomet metformin hydrochloride PDR
Max dose for children 2000.0 mg/day 2000 mg/day Liquid Riomet metformin hydrochloride PDR
Max dose for adolescents 2000.0 mg/day 2000 mg/day Tablet,PO，oral;Liquid; Riomet metformin hydrochloride PDR
Max dose for adolescents 2000.0 mg/day 2000 mg/day Liquid Riomet metformin hydrochloride PDR
Max dose for adults 2550.0 mg/day 2550 mg/day Tablet,PO，oral;Liquid; Riomet metformin hydrochloride PDR
Max dose for adults 2000.0 mg/day 2000 mg/day Liquid Riomet metformin hydrochloride PDR
Max dose for adults 2250.0 mg/day 2250 mg/day Tablet,PO，oral Riomet metformin hydrochloride PDR
Max dose for geriatric 2550.0 mg/day 2550 mg/day Tablet,PO，oral;Liquid; Riomet metformin hydrochloride PDR
Max dose for geriatric 2000.0 mg/day 2000 mg/day Liquid Riomet metformin hydrochloride PDR
Max dose for geriatric 2250.0 mg/day 2250 mg/day Tablet,PO，oral Riomet metformin hydrochloride PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1