Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00327 ...
Drug Name Hydromorphone
Molecular Weight 285.3377
Molecular Formula C17H19NO3
CAS Number 466-99-9
SMILES [H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(C)[C@]([H])(C4)[C@]1([H])CCC2=O
External Links
DRUGBANK DB00327
T3DB T3D2752
PubChem Compound 5284570
PDR 2473
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.06 - 1.06 - Agilent. SAMHSA-Compilant Analysis of Opiates.
Boiling Point 305.0 ℃ 305 ℃ 'MSDS'
Melting Point 305.0 ℃ 305 ℃ 'MSDS'
pKa 8.2 - 8.2 - Agilent. SAMHSA-Compilant Analysis of Opiates.

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
AUC 34.0 ng.h/ml 34.0 ng.h/ml PO, oral; DRUGBANK
Bioavailability 60.0 % 60.0 % PO, oral; DRUGBANK
Bioavailability 78.0 % 78.0 % parenteral administration; DRUGBANK
Bioavailability 42.0 % 42±23 % PO, oral; Male, men; normal,healthy; The Pharmacological Basis of Therapeutics
Bioavailability 80.0 % ~80 % subcutaneous injection, SC; Male, men; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 0 null ~0 null parenteral administration; DRUGBANK
C Max 11.8 ng/ml 11.8±2.6 ng/ml PO, oral; Male, men; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 242.0 ng/ml 242.0 ng/ml intravenous injection, IV; Male, men; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 0.75 h 0.5-1 h PO, oral; immediate release formulation; DRUGBANK
T Max 9.0 h >9 h PO, oral; extended release formulation; extended release formulation ↑ ; DRUGBANK
T Max 1.1 h 1.1±0.2 h PO, oral; Male, men; normal,healthy; The Pharmacological Basis of Therapeutics
Metabolic 62.0 % 62 % Liver metabolism; DRUGBANK
Clearance 6.3 L/h 105.7 ml/min Plasma clearance; DRUGBANK
Clearance 117.6 L/h 1.96 L/min Total clearance; DRUGBANK
Clearance 0.88 L/h/kg 14.6±7.6 ml/min/kg The Pharmacological Basis of Therapeutics
Clearance 1.7 L/h/kg 28 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 4.0 L/kg 4.0 L/kg DRUGBANK
Volume of Distribution 2.9 L/kg 2.90±1.31 L/kg Apparent volume of distribution; The Pharmacological Basis of Therapeutics
Volume of Distribution 4.3 L/kg 4.3 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.5 h 2-3 h immediate release formulation; DRUGBANK
Half-life 11.5 h 8-15 h extended release formulation; DRUGBANK
Half-life 2.4 h 2.4±0.6 h normal,healthy; Male, men; The Pharmacological Basis of Therapeutics
Half-life 2.3 h 2.3 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 104.0 mg/kg 104.0 mg/kg intravenous injection, IV; mouse; DRUGBANK
Toxicity LD50 84.0 mg/kg 84.0 mg/kg PO, oral; mouse; DRUGBANK
Eliminate Route 6.0 % 6 % Urinary excretion; Male, men; normal,healthy; human, homo sapiens; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 13.5 % ~8-19 % DRUGBANK
Protein Binding 7.1 % 7.1 % Male, men; normal,healthy; human, homo sapiens; The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1