Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00320 ...
Drug Name Dihydroergotamine
Molecular Weight 583.6774
Molecular Formula C33H37N5O5
CAS Number 511-12-6
SMILES [H][C@@]12CCCN1C(=O)[C@H](CC1=CC=CC=C1)N1C(=O)[C@](C)(NC(=O)[C@H]3CN(C)[C@]4([H])CC5=CNC6=CC=CC(=C56)[C@@]4([H])C3)O[C@@]21O
External Links
DRUGBANK DB00320
T3DB T3D2750
PubChem Compound 10531
PDR 1552
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.0 - 2.0 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 90.0 L/h 1.5 L/min DRUGBANK
Clearance 0.90 L/h/kg 15.07 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 800.0 L 800.0 L DRUGBANK
Volume of Distribution 0.33 L/kg 0.33 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 9.0 h 9 h DRUGBANK
Half-life 0.55 h 0.55 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 6.5 % 6-7 % Urinary excretion; IM,intramuscular injection; Unchanged drug; DRUGBANK
Protein Binding 93.0 % 93 % plasma proteins; DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for children 0.5 mg/dose 0.5 mg/dose IM,intramuscular injection bid D.H.E 45 dihydroergotamine mesylate PDR
Max dose for children 0.25 mg/dose 0.25 mg/dose intravenous injection, IV bid D.H.E 45 dihydroergotamine mesylate PDR
Max dose for children 0.14285714 mg/day 1 mg/week D.H.E 45 dihydroergotamine mesylate PDR
Max dose for children 0.0 0 D.H.E 45 dihydroergotamine mesylate PDR
Max dose for adolescents 0.5 mg/dose 0.5 mg/dose IM,intramuscular injection bid D.H.E 45 dihydroergotamine mesylate PDR
Max dose for adolescents 0.25 mg/dose 0.25 mg/dose intravenous injection, IV bid D.H.E 45 dihydroergotamine mesylate PDR
Max dose for adolescents 0.142857142857143 mg/day 1 mg/week D.H.E 45 dihydroergotamine mesylate PDR
Max dose for adults 1.0 mg/dose 1 mg/dose intravenous injection, IV;IM,intramuscular injection; D.H.E 45 dihydroergotamine mesylate PDR
Max dose for adults 3.0 mg/day 3 mg/day IM,intramuscular injection D.H.E 45 dihydroergotamine mesylate PDR
Max dose for adults 2.0 mg/day 2 mg/day intravenous injection, IV D.H.E 45 dihydroergotamine mesylate PDR
Max dose for adults 0.857142857142857 mg/day 6 mg/week D.H.E 45 dihydroergotamine mesylate PDR
Max dose for elderly 1.0 mg/dose 1 mg/dose intravenous injection, IV;IM,intramuscular injection; D.H.E 45 dihydroergotamine mesylate PDR
Max dose for elderly 3.0 mg/day 3 mg/day IM,intramuscular injection D.H.E 45 dihydroergotamine mesylate PDR
Max dose for elderly 2.0 mg/day 2 mg/day intravenous injection, IV D.H.E 45 dihydroergotamine mesylate PDR
Max dose for elderly 0.857142857142857 mg/day 6 mg/week D.H.E 45 dihydroergotamine mesylate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1