Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00318 ...
Drug Name Codeine
Molecular Weight 299.3642
Molecular Formula C18H21NO3
CAS Number 76-57-3
SMILES [H][C@]12C=C[C@H](O)[C@@H]3OC4=C5C(C[C@H]1N(C)CC[C@@]235)=CC=C4OC
External Links
DRUGBANK DB00318
T3DB T3D2749
PubChem Compound 5284371
PDR 2672
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.39 - 1.39 - https://www.agilent.com/cs/library/applications/5990-9625EN.pdf
Boiling Point 250.0 ℃ 250 ℃ http://www.chm.bris.ac.uk/webprojects2002/winder/information.htm
Melting Point 155.0 ℃ 154-156 ℃ MSDS
pKa 8.2 - 8.2 - http://www.inchem.org/documents/pims/pharm/codeine.htm
Log S -1.52 - -1.52 - ADMET & DMPK 1(4) (2013) 48-62; doi: 10.5599/admet.1.4.24

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 50.0 % 50±7 % PO, oral; intravenous injection, IV; The Pharmacological Basis of Therapeutics
C Max 149.0 ng/ml 149±60 ng/ml PO, oral; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 3.8 ng/ml 3.8±2.4 ng/ml PO, oral; Active metabolite; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.0 h 1 h PO, oral; DRUGBANK
T Max 1.0 h 1.0±0.5 h PO, oral; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 1.0 h 1.0±0.4 h PO, oral; Active metabolite; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Tss 120.0 h 5.0 day DRUGBANK
Metabolic 75.0 % 70-80 % Liver metabolism; DRUGBANK
Clearance 11.0 L/h 183±59 ml/min RD, renal impairment, Renal disease，including uremia ↓ ; DRUGBANK
Clearance 0.66 L/h/kg 11±2 ml/min/kg apparent clearance; hydrolysis; The Pharmacological Basis of Therapeutics
Clearance 0.90 L/h/kg 15 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 4.5 L/kg ~3-6.0 L/kg Apparent volume of distribution; DRUGBANK
Volume of Distribution 2.6 L/kg 2.6±0.3 L/kg Apparent volume of distribution; hydrolysis; The Pharmacological Basis of Therapeutics
Volume of Distribution 3.5 L/kg 3.5 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 3.0 h ~3 h elimination half-life; DRUGBANK
Half-life 3.0 h ~3 h elimination half-life; Metabolite; DRUGBANK
Half-life 2.9 h 2.9±0.7 h The Pharmacological Basis of Therapeutics
Half-life 4.0 h 4 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 427.0 mg/kg 427.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Eliminate Route 90.0 % ~90 % Urinary excretion; DRUGBANK
Eliminate Route 10.0 % ~10 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 0 % ~0 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 16.0 % 7-25 % plasma proteins; DRUGBANK
Protein Binding 7.0 % 7 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for infants 0.0 0 Codeine Sulfate Tablets codeine sulfate PDR
Max dose for children 1.0 mg/kg/dose 1 mg/kg/dose Codeine Sulfate Tablets codeine sulfate PDR
Max dose for children 60.0 mg/dose 60 mg/dose Codeine Sulfate Tablets codeine sulfate PDR
Max dose for children 0.0 0 Codeine Sulfate Tablets codeine sulfate PDR
Max dose for adolescents 1.0 mg/kg/dose 1 mg/kg/dose Codeine Sulfate Tablets codeine sulfate PDR
Max dose for adolescents 60.0 mg/dose 60 mg/dose Codeine Sulfate Tablets codeine sulfate PDR
Max dose for adults 60.0 mg/dose 60 mg/dose PO, oral Codeine Sulfate Tablets codeine sulfate PDR
Max dose for adults 360.0 mg/day 360 mg/day PO, oral Codeine Sulfate Tablets codeine sulfate PDR
Max dose for geriatric 60.0 mg/dose 60 mg/dose PO, oral Codeine Sulfate Tablets codeine sulfate PDR
Max dose for geriatric 360.0 mg/day 360 mg/day PO, oral Codeine Sulfate Tablets codeine sulfate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1