Property Name |
Property Value |
Unit |
Raw Value |
Raw Unit |
Annotation |
Factor |
Reference |
Bioavailability |
60.0 |
% |
60.0 |
% |
PO, oral; |
|
DRUGBANK |
Bioavailability |
60.0 |
% |
60.0 |
% |
PO, oral; |
|
The Pharmacological Basis of Therapeutics |
C Max |
341.0 |
ng/ml |
341±208 |
ng/ml |
PO, oral; tumor; |
|
The Pharmacological Basis of Therapeutics |
T Max |
5.0 |
h |
3-7 |
h |
PO, oral; |
|
DRUGBANK |
T Max |
5.0 |
h |
5(3-7) |
h |
PO, oral; tumor; |
|
The Pharmacological Basis of Therapeutics |
Clearance |
35.7 |
L/h |
595.0 |
ml/min |
intravenous injection, IV; |
|
DRUGBANK |
Clearance |
0.44 |
L/h/kg |
7.3(2.8-21) |
ml/min/kg |
hydrolysis; tumor; patients; |
|
The Pharmacological Basis of Therapeutics |
Clearance |
0.72 |
L/h/kg |
12 |
ml/min/kg |
intravenous injection, IV; human, homo sapiens; |
|
Human Intravenous Pharmacokinetic Dataset |
Volume of Distribution |
1400.0 |
L |
1400.0 |
L |
intravenous injection, IV; |
|
DRUGBANK |
Volume of Distribution |
20.0 |
L/kg |
20(12-39) |
L/kg |
hydrolysis; tumor; patients; |
|
The Pharmacological Basis of Therapeutics |
Volume of Distribution |
23.0 |
L/kg |
23 |
L/kg |
intravenous injection, IV; human, homo sapiens; |
|
Human Intravenous Pharmacokinetic Dataset |
Half-life |
48.0 |
h |
48 |
h |
intravenous injection, IV; |
|
DRUGBANK |
Half-life |
48.0 |
h |
48(10-136) |
h |
|
|
The Pharmacological Basis of Therapeutics |
Half-life |
34.0 |
h |
34 |
h |
intravenous injection, IV; human, homo sapiens; |
|
Human Intravenous Pharmacokinetic Dataset |
Toxicity Lethal Dose |
12000.0 |
mg/m2 |
12000.0 |
mg/m2 |
Single dose; Rattus, Rat; |
|
DRUGBANK |
Eliminate Route |
86.0 |
% |
86 |
% |
Faeces excretion; |
|
DRUGBANK |
Eliminate Route |
1.0 |
% |
<1 |
% |
Urinary excretion; tumor; Unchanged drug; |
|
The Pharmacological Basis of Therapeutics |
Protein Binding |
90.0 |
% |
90 |
% |
|
Plasma Concentration → ; |
DRUGBANK |
Protein Binding |
90.0 |
% |
90 |
% |
tumor; |
|
The Pharmacological Basis of Therapeutics |