Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00316 ...
Drug Name Acetaminophen
Molecular Weight 151.1626
Molecular Formula C8H9NO2
CAS Number 103-90-2
SMILES CC(=O)NC1=CC=C(O)C=C1
External Links
DRUGBANK DB00316
T3DB T3D2571
PubChem Compound 1983
PDR 1346
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 0.91 - 0.91 - http://www.t3db.ca/toxins/T3D2571
Boiling Point 500.0 ℃ >500 ℃ http://www.inchem.org/documents/icsc/icsc/eics1330.htm
Melting Point 170.0 ℃ 170 ℃ MSDS
pKa -4.4 - -4.4 - http://www.t3db.ca/toxins/T3D2571
Log S -1.6 - -1.6 - http://www.t3db.ca/toxins/T3D2571

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 88.0 % 88.0 % PO, oral; DRUGBANK
Bioavailability 88.0 % 88±15 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 20000.0 ng/ml 20 ug/ml PO, oral; The Pharmacological Basis of Therapeutics
T Max 1.5 h 1.5 h PO, oral; DRUGBANK
T Max 3.0 h 3 h Rectal Administration; DRUGBANK
T Max 0.87 h 0.33-1.4 h PO, oral; The Pharmacological Basis of Therapeutics
Clearance 0.27 L/h/kg 0.27 L/h/kg intravenous injection, IV; adults; DRUGBANK
Clearance 0.34 L/h/kg 0.34 L/h/kg intravenous injection, IV; Children; DRUGBANK
Clearance 0.30 L/h/kg 5.0±1.4 ml/min/kg normal,healthy; adults; Children → ;Elderly → ;Preg, pregnant ↑ ;Hepatitis, Hep ↓ ;Obesity ↑ ;hyperthyroid, HTh ↑ ; The Pharmacological Basis of Therapeutics
Clearance 0.30 L/h/kg 5 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.90 L/kg 0.9 L/kg DRUGBANK
Volume of Distribution 0.95 L/kg 0.95±0.12 L/kg normal,healthy; adults; Children → ;Elderly → ;Hepatitis, Hep → ;hyperthyroid, HTh → ;LTh hypothyroid → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 1.0 L/kg 1 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 2.5 h 2.5 h intravenous injection, IV; adults; DRUGBANK
Half-life 6.0 h 4-8 h hepatopathy，LD; overdose; DRUGBANK
Half-life 2.0 h 2.0±0.4 h Children → ;Neonates ↑ ;Preg, pregnant ↓ ;RD, renal impairment, Renal disease，including uremia → ;Obesity → ;Hepatitis, Hep ↑ ;hyperthyroid, HTh ↓ ; The Pharmacological Basis of Therapeutics
Half-life 2.5 h 2.5 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 338.0 mg/kg 338.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 1944.0 mg/kg 1944.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 338.0 mg/kg 338.0 mg/kg PO, oral; mouse; T3DB
Toxicity LD50 1944.0 mg/kg 1944.0 mg/kg PO, oral; Rattus, Rat; T3DB
Toxicity Lethal Dose 25000.0 mg 25.0 g adults; human, homo sapiens; T3DB
Eliminate Route 90.0 % >90 % DRUGBANK
Eliminate Route 3.0 % 3±1 % Urinary excretion; Unchanged drug; Neonates → ;Children → ; The Pharmacological Basis of Therapeutics
Protein Binding 17.5 % 10-25 % plasma proteins; DRUGBANK
Protein Binding 20.0 % <20 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Frequency Brand Name Component Reference
Max dose for neonates 90.0 mg/kg/day 90 mg/kg/day PO, oral Ofirmev acetaminophen PDR
Max dose for neonates 90.0 mg/kg/day 90 mg/kg/day Rectal Administration Ofirmev acetaminophen PDR
Max dose for neonates 50.0 mg/kg/day 50 mg/kg/day intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for neonates 60.0 mg/kg/day 60 mg/kg/day intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for neonates 60.0 mg/kg/day 60 mg/kg/day PO, oral Ofirmev acetaminophen PDR
Max dose for neonates 60.0 mg/kg/day 60 mg/kg/day Rectal Administration Ofirmev acetaminophen PDR
Max dose for neonates 50.0 mg/kg/day 50 mg/kg/day intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for neonates 60.0 mg/kg/day 60 mg/kg/day intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for neonates 60.0 mg/kg/day 60 mg/kg/day PO, oral Ofirmev acetaminophen PDR
Max dose for neonates 60.0 mg/kg/day 60 mg/kg/day Rectal Administration Ofirmev acetaminophen PDR
Max dose for neonates 50.0 mg/kg/day 50 mg/kg/day intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for neonates 40.0 mg/kg/day 40 mg/kg/day intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for neonates 40.0 mg/kg/day 40 mg/kg/day PO, oral;Rectal Administration; Ofirmev acetaminophen PDR
Max dose for neonates 22.5 mg/kg/day 22.5 mg/kg/day intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for infants 75.0 mg/kg/day 75 mg/kg/day PO, oral qd Ofirmev acetaminophen PDR
Max dose for infants 75.0 mg/kg/day 75 mg/kg/day Rectal Administration qd Ofirmev acetaminophen PDR
Max dose for infants 60.0 mg/kg/day 60 mg/kg/day intravenous injection, IV qd Ofirmev acetaminophen PDR
Max dose for children 4000.0 mg/day 4000 mg/day PO, oral;Rectal Administration; Ofirmev acetaminophen PDR
Max dose for children 750.0 mg/dose 750 mg/dose intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for children 75.0 mg/kg/day 75 mg/kg/day intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for children 3750.0 mg/day 3750 mg/day intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for children 75.0 mg/kg/day 75 mg/kg/day PO, oral Ofirmev acetaminophen PDR
Max dose for children 4000.0 mg/day 4000 mg/day PO, oral Ofirmev acetaminophen PDR
Max dose for children 1000.0 mg/dose 1000 mg/dose Rectal Administration Ofirmev acetaminophen PDR
Max dose for children 100.0 mg/kg/day 100 mg/kg/day Rectal Administration Ofirmev acetaminophen PDR
Max dose for children 4000.0 mg/day 4000 mg/day Rectal Administration Ofirmev acetaminophen PDR
Max dose for children 750.0 mg/dose 750 mg/dose intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for children 75.0 mg/kg/day 75 mg/kg/day intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for children 3750.0 mg/day 3750 mg/day intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for children 75.0 mg/kg/day 75 mg/kg/day PO, oral;intravenous injection, IV; Ofirmev acetaminophen PDR
Max dose for children 3750.0 mg/day 3750 mg/day PO, oral;intravenous injection, IV; Ofirmev acetaminophen PDR
Max dose for children 100.0 mg/kg/day 100 mg/kg/day Rectal Administration Ofirmev acetaminophen PDR
Max dose for children 4000.0 mg/day 4000 mg/day Rectal Administration Ofirmev acetaminophen PDR
Max dose for children 75.0 mg/kg/day 75 mg/kg/day PO, oral Ofirmev acetaminophen PDR
Max dose for children 100.0 mg/kg/day 100 mg/kg/day Rectal Administration Ofirmev acetaminophen PDR
Max dose for children 60.0 mg/kg/day 60 mg/kg/day intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for adolescents 4000.0 mg/day 4000 mg/day PO, oral;Rectal Administration;intravenous injection, IV; Ofirmev acetaminophen PDR
Max dose for adolescents 75.0 mg/kg/day 75 mg/kg/day PO, oral Ofirmev acetaminophen PDR
Max dose for adolescents 4000.0 mg/day 4000 mg/day PO, oral Ofirmev acetaminophen PDR
Max dose for adolescents 1000.0 mg/dose 1000 mg/dose Rectal Administration Ofirmev acetaminophen PDR
Max dose for adolescents 100.0 mg/kg/day 100 mg/kg/day Rectal Administration Ofirmev acetaminophen PDR
Max dose for adolescents 4000.0 mg/day 4000 mg/day Rectal Administration Ofirmev acetaminophen PDR
Max dose for adolescents 4000.0 mg/day 4000 mg/day intravenous injection, IV Ofirmev acetaminophen PDR
Max dose for adolescents 75.0 mg/kg/day 75 mg/kg/day PO, oral;intravenous injection, IV; Ofirmev acetaminophen PDR
Max dose for adolescents 3750.0 mg/day 3750 mg/day PO, oral;intravenous injection, IV; Ofirmev acetaminophen PDR
Max dose for adolescents 100.0 mg/kg/day 100 mg/kg/day Rectal Administration Ofirmev acetaminophen PDR
Max dose for adolescents 4000.0 mg/day 4000 mg/day Rectal Administration Ofirmev acetaminophen PDR
Max dose for adults 4000.0 mg/day 4000 mg/day PO, oral;intravenous injection, IV;Rectal Administration; Ofirmev acetaminophen PDR
Max dose for adults 1300.0 mg/dose 1300 mg/dose PO, oral Ofirmev acetaminophen PDR
Max dose for adults 4000.0 mg/day 4000 mg/day PO, oral qd Ofirmev acetaminophen PDR
Max dose for geriatric 4000.0 mg/day 4000 mg/day PO, oral;intravenous injection, IV;Rectal Administration; Ofirmev acetaminophen PDR
Max dose for geriatric 1300.0 mg/dose 1300 mg/dose PO, oral Ofirmev acetaminophen PDR
Max dose for geriatric 4000.0 mg/day 4000 mg/day PO, oral qd Ofirmev acetaminophen PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1