Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00313 ...
Drug Name Valproic acid
Molecular Weight 144.2114
Molecular Formula C8H16O2
CAS Number 99-66-1
SMILES CCCC(CCC)C(O)=O
External Links
DRUGBANK DB00313
T3DB T3D2558
PubChem Compound 3121
PDR 1075
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.75 - 2.75 - ChemIDplus
Boiling Point 222.0 ℃ 222 ℃ ChemIDplus
Water Solubility 1300.0 mg/L 1.3 mg/ml FDA label 2006)
pKa 4.8 - 4.8 - FDA label (2006)
Log S -1.86 - -1.86 - ADME Research, USCD

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Bioavailability 90.0 % ~90 % PO, oral; DRUGBANK
Bioavailability 100.0 % ~100 % PO, oral; extended release formulation; extended release formulation ↑ ; DRUGBANK
Bioavailability 100.0 % 100±10 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 34000.0 ng/ml 34±8 mcg/ml Capsule, PO, Oral; Drug form; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 4.0 h 4 h Tablet, PO, oral; extended release formulation; DRUGBANK
T Max 8.0 h 8 h Tablet, PO, oral; extended release formulation; food; food ↑ ; DRUGBANK
T Max 4.1 h 3.3-4.8 h Capsule, PO, Oral; DRUGBANK
T Max 2.5 h 1-4 h Capsule, PO, Oral; Drug form; Male, men; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 10.5 h 7-14 h Capsule, PO, Oral; Drug form; extended release formulation; The Pharmacological Basis of Therapeutics
Clearance 0.56 L/h/m2 0.56 L/h/m2 DRUGBANK
Clearance 0.006600 L/h/kg 0.11±0.02 ml/min/kg Multiple dose; Children ↑ ;Elderly → ;Hepatic cirrhosis, cirr → ; The Pharmacological Basis of Therapeutics
Clearance 0.009600 L/h/kg 0.16 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 6.4 L/m2 11.0 l/1.73m2 DRUGBANK
Volume of Distribution 0.22 L/kg 0.22±0.07 L/kg Neonates ↑ ;Children → ;Elderly → ;Hepatic cirrhosis, cirr ↑ ; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.14 L/kg 0.14 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 16.0 h 13-19 h DRUGBANK
Half-life 14.0 h 14±3 h Multiple dose; Neonates ↑ ;Children ↓ ;Hepatic cirrhosis, cirr ↑ ;Age ↑ ;normal BMI ↓ ; The Pharmacological Basis of Therapeutics
Half-life 9.8 h 9.8±2.6 h Single dose; The Pharmacological Basis of Therapeutics
Half-life 12.0 h 12 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Toxicity LD50 1098.0 mg/kg 1098.0 mg/kg PO, oral; mouse; DRUGBANK
Toxicity LD50 670.0 mg/kg 670.0 mg/kg PO, oral; Rattus, Rat; DRUGBANK
Toxicity LD50 1098.0 mg/kg 1098.0 mg/kg PO, oral; mouse; T3DB
Toxicity LD50 670.0 mg/kg 670.0 mg/kg PO, oral; Rattus, Rat; T3DB
Eliminate Route 3.0 % <3 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 1.8 % 1.8±2.4 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 10.0 % 10 % DRUGBANK
Protein Binding 18.5 % 18.5 % DRUGBANK
Protein Binding 93.0 % 93±1 % Preg, pregnant ↓ ;Elderly ↓ ;Neonates ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ;Hepatic cirrhosis, cirr ↓ ;Burn ↓ ;hypoalbuminemia Alb ↓ ; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 60.0 mg/kg/day 60 mg/kg/day PO, oral;intravenous injection, IV; Depakote Tablets divalproex sodium PDR
Max dose for adolescents 60.0 mg/kg/day 60 mg/kg/day PO, oral;intravenous injection, IV; Depakote Tablets divalproex sodium PDR
Max dose for adolescents 1000.0 mg/kg/day 1000 mg/kg/day PO, oral Depakote Tablets divalproex sodium PDR
Max dose for adolescents 60.0 mg/kg/day 60 mg/kg/day PO, oral;intravenous injection, IV; Depakote Tablets divalproex sodium PDR
Max dose for adults 60.0 mg/kg/day 60 mg/kg/day PO, oral;intravenous injection, IV; Depakote Tablets divalproex sodium PDR
Max dose for adults 1000.0 mg/kg/day 1000 mg/kg/day PO, oral Depakote Tablets divalproex sodium PDR
Max dose for adults 60.0 mg/kg/day 60 mg/kg/day PO, oral Depakote Tablets divalproex sodium PDR
Max dose for elderly 60.0 mg/kg/day 60 mg/kg/day PO, oral;intravenous injection, IV; Depakote Tablets divalproex sodium PDR
Max dose for elderly 1000.0 mg/kg/day 1000 mg/kg/day PO, oral Depakote Tablets divalproex sodium PDR
Max dose for elderly 60.0 mg/kg/day 60 mg/kg/day PO, oral Depakote Tablets divalproex sodium PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1