Basic Information
| Drug ID | DDPD00312 |
|
| Drug Name | Pentobarbital | |
| Molecular Weight | 226.2722 | |
| Molecular Formula | C11H18N2O3 | |
| CAS Number | 76-74-4 | |
| SMILES | CCCC(C)C1(CC)C(=O)NC(=O)NC1=O | |
| External Links | ||
| DRUGBANK | DB00312 | |
| T3DB | T3D2745 | |
| PubChem Compound | 4737 | |
| PDR | 2052 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.1 | - | 2.1 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 129.5 | ℃ | 129.5 | ℃ | PhysProp |
| Water Solubility | 679.0 | mg/L | 679 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 8.11 | - | 8.11 | - | SERJEANT,EP & DEMPSEY,B (1979) |
| Log S | -2.52 | - | -2.52 | - | ADME Research, USCD |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.0282 | L/h/kg | 0.47 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.91 | L/kg | 0.91 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 27.5 | h | 5-50 | h | DRUGBANK | Half-life | 22.0 | h | 22 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 37.5 | % | ~25-50 | % | Urinary excretion; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 6.0 | mg/kg/dose | 6 | mg/kg/dose | intravenous injection, IV | Nembutal | pentobarbital sodium | PDR |
| Max dose for infants | 6.0 | mg/kg/dose | 6 | mg/kg/dose | IM,intramuscular injection;intravenous injection, IV; | Nembutal | pentobarbital sodium | PDR |
| Max dose for infants | 8.0 | mg/kg/dose | 8 | mg/kg/dose | PO, oral | Nembutal | pentobarbital sodium | PDR |
| Max dose for infants | 100.0 | mg/dose | 100 | mg/dose | PO, oral | Nembutal | pentobarbital sodium | PDR |
| Max dose for children | 6.0 | mg/kg/dose | 6 | mg/kg/dose | IM,intramuscular injection;intravenous injection, IV;PO, oral; | Nembutal | pentobarbital sodium | PDR |
| Max dose for children | 100.0 | mg/dose | 100 | mg/dose | IM,intramuscular injection;intravenous injection, IV;PO, oral; | Nembutal | pentobarbital sodium | PDR |
| Max dose for adolescents | 6.0 | mg/kg/dose | 6 | mg/kg/dose | IM,intramuscular injection;intravenous injection, IV;PO, oral; | Nembutal | pentobarbital sodium | PDR |
| Max dose for adolescents | 100.0 | mg/dose | 100 | mg/dose | IM,intramuscular injection;intravenous injection, IV;PO, oral; | Nembutal | pentobarbital sodium | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1