Basic Information
| Drug ID | DDPD00310 |
|
| Drug Name | Chlorthalidone | |
| Molecular Weight | 338.766 | |
| Molecular Formula | C14H11ClN2O4S | |
| CAS Number | 77-36-1 | |
| SMILES | NS(=O)(=O)C1=C(Cl)C=CC(=C1)C1(O)NC(=O)C2=CC=CC=C12 | |
| External Links | ||
| DRUGBANK | DB00310 | |
| PubChem Compound | 2732 | |
| PDR | 1961 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.85 | - | 0.85 | - | BERTHOD,A ET AL. (1999) |
| Melting Point | 239.0 | ℃ | 239 | ℃ | PhysProp |
| Water Solubility | 120.0 | mg/L | 120 | mg/L | MERCK INDEX 1996) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 64.0 | % | 64±10 | % | PO, oral; | The Pharmacological Basis of Therapeutics | |
| C Max | 3700.0 | ng/ml | 3.7±0.9 | mcg/ml | Male, men; adults; normal,healthy; | The Pharmacological Basis of Therapeutics | |
| T Max | 13.8 | h | 13.8±6.3 | h | Male, men; adults; normal,healthy; | The Pharmacological Basis of Therapeutics | |
| Clearance | 0.002400 | L/h/kg | 0.04±0.01 | ml/min/kg | Elderly ↓ ; | The Pharmacological Basis of Therapeutics | Clearance | 0.0900 | L/h/kg | 1.5 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.14 | L/kg | 0.14±0.07 | L/kg | The Pharmacological Basis of Therapeutics | Volume of Distribution | 3.9 | L/kg | 3.9 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 45.0 | h | 40-50 | h | DRUGBANK | Half-life | 47.0 | h | 47±22 | h | Age ↑ ; | The Pharmacological Basis of Therapeutics | Half-life | 36.0 | h | 36 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 50.0 | % | ~50 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 65.0 | % | 65±9 | % | Urinary excretion; Unchanged drug; | The Pharmacological Basis of Therapeutics |
| Protein Binding | 75.0 | % | ~75 | % | plasma proteins; | DRUGBANK | Protein Binding | 58.0 | % | 58 | % | DRUGBANK | Protein Binding | 75.0 | % | 75±1 | % | The Pharmacological Basis of Therapeutics |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 2.0 | mg/kg/day | 2 | mg/kg/day | PO, oral | Chlorthalidone | chlorthalidone | PDR |
| Max dose for children | 50.0 | mg/day | 50 | mg/day | PO, oral | Chlorthalidone | chlorthalidone | PDR |
| Max dose for adolescents | 2.0 | mg/kg/day | 2 | mg/kg/day | PO, oral | Chlorthalidone | chlorthalidone | PDR |
| Max dose for adolescents | 50.0 | mg/day | 50 | mg/day | PO, oral | Chlorthalidone | chlorthalidone | PDR |
| Max dose for adults | 100.0 | mg/day | 100 | mg/day | PO, oral | Chlorthalidone | chlorthalidone | PDR |
| Max dose for adults | 200.0 | mg/day | 200 | mg/day | PO, oral | Chlorthalidone | chlorthalidone | PDR |
| Max dose for geriatric | 100.0 | mg/day | 100 | mg/day | PO, oral | Chlorthalidone | chlorthalidone | PDR |
| Max dose for geriatric | 200.0 | mg/day | 200 | mg/day | PO, oral | Chlorthalidone | chlorthalidone | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1