Basic Information
| Drug ID | DDPD00305 |
|
| Drug Name | Mitomycin | |
| Molecular Weight | 334.3272 | |
| Molecular Formula | C15H18N4O5 | |
| CAS Number | 50-07-7 | |
| SMILES | [H][C@]12CN3C4=C([C@@H](COC(N)=O)[C@@]3(OC)[C@@]1([H])N2)C(=O)C(N)=C(C)C4=O | |
| External Links | ||
| DRUGBANK | DB00305 | |
| T3DB | T3D2743 | |
| PubChem Compound | 5746 | |
| PDR | 1230 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -0.4 | - | -0.4 | - | HANSCH,C ET AL. (1995) |
| Boiling Point | 534.0 | ℃ | 534 | ℃ | PhysProp |
| Melting Point | 360.0 | ℃ | >360 | ℃ | PhysProp |
| Water Solubility | 8430.0 | mg/L | 8430 | mg/L | DRUGBANK |
| pKa | 10.9 | - | 10.9 | - | HANSCH,C ET AL. (1995) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Half-life | 0.47 | h | 8-48 | min | DRUGBANK | |
| Toxicity LD50 | 23.0 | mg/kg | 23.0 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 30.0 | mg/kg | 30.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 23.0 | mg/kg | 23.0 | mg/kg | PO, oral; mouse; | T3DB | Toxicity LD50 | 30.0 | mg/kg | 30.0 | mg/kg | PO, oral; Rattus, Rat; | T3DB |
| Eliminate Route | 10.0 | % | ~10 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adolescents | 20.0 | mg/m2 | 20 | mg/m2 | intravenous injection, IV | Mitomycin | mitomycin | PDR |
| Max dose for adolescents | 60.0 | mg | 60 | mg | Mitomycin | mitomycin | PDR | |
| Max dose for adolescents | 15.0 | ml | 15 | mL | Mitomycin | mitomycin | PDR | |
| Max dose for geriatric | 20.0 | mg/m2 | 20 | mg/m2 | intravenous injection, IV | Mitomycin | mitomycin | PDR |
| Max dose for geriatric | 60.0 | mg | 60 | mg | Mitomycin | mitomycin | PDR | |
| Max dose for geriatric | 15.0 | ml | 15 | ml | Mitomycin | mitomycin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1