Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00296 ...
Drug Name Ropivacaine
Molecular Weight 274.4011
Molecular Formula C17H26N2O
CAS Number 84057-95-4
SMILES CCCN1CCCC[C@H]1C(=O)NC1=C(C)C=CC=C1C
External Links
DRUGBANK DB00296
T3DB T3D2741
PubChem Compound 175805
PDR 24350
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.9 - 2.9 - HANSCH,C ET AL. (1995)
Water Solubility 57.6 mg/L 57.6 mg/L DRUGBANK
pKa 8.07 - 8.07 - DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Bioavailability 92.5 % 87-98 % epidural administration; DRUGBANK
C Max 1100.0 ng/ml 1.1±0.2 mcg/ml The Pharmacological Basis of Therapeutics
C Max 2300.0 ng/ml 2.3±0.8 mcg/ml skin/dermal; The Pharmacological Basis of Therapeutics
T Max 0.70 h 0.7±0.2 h The Pharmacological Basis of Therapeutics
T Max 0.90 h 0.9±0.4 h skin/dermal; The Pharmacological Basis of Therapeutics
Clearance 23.2 L/h 387±107 ml/min DRUGBANK
Clearance 432.0 L/h 7.2±1.6 L/min Plasma clearance; DRUGBANK
Clearance 0.38 L/h/kg 5.5-7.1 ml/min/kg Average clearance; The Pharmacological Basis of Therapeutics
Clearance 0.33 L/h/kg 5.5 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.70 L/kg 0.54-0.86 L/kg Average volume of distribution; The Pharmacological Basis of Therapeutics
Volume of Distribution 0.75 L/kg 0.75 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 4.2 h ~4.2 h DRUGBANK
Half-life 1.8 h 1.6-2.0 h different study; The Pharmacological Basis of Therapeutics
Half-life 5.5 h 4-7 h epidural administration; IM,intramuscular injection; The Pharmacological Basis of Therapeutics
Half-life 2.2 h 2.2 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 86.0 % 86 % Urinary excretion; intravenous injection, IV; DRUGBANK
Eliminate Route 1.0 % 1 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 94.0 % 94 % DRUGBANK
Protein Binding 92.0 % 90-94 % The Pharmacological Basis of Therapeutics

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1