Basic Information Experimental Physicochemical Property Pharmacokinetic/Toxicokinetic Property Maximum Dosage Drug Property Radar Chart

Basic Information

Drug ID DDPD00285 ...
Drug Name Venlafaxine
Molecular Weight 277.4018
Molecular Formula C17H27NO2
CAS Number 93413-69-5
SMILES COC1=CC=C(C=C1)C(CN(C)C)C1(O)CCCCC1
External Links
DRUGBANK DB00285
T3DB T3D2736
PubChem Compound 5656
PDR 1361
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 231.0 ℃ 215-217 ℃ DRUGBANK
Water Solubility 572000.0 mg/L 572 mg/ml DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Factor Reference
Absorption 92.0 % 92.0 % Oral single dose; food; food → ; DRUGBANK
Bioavailability 45.0 % 45.0 % Oral single dose; food; food → ; DRUGBANK
Bioavailability 27.5 % 10-45 % PO, oral; The Pharmacological Basis of Therapeutics
C Max 167.0 ng/ml 167±55 ng/ml PO, oral; immediate release formulation; adults; normal,healthy; The Pharmacological Basis of Therapeutics
C Max 397.0 ng/ml 397±81 ng/ml PO, oral; Active metabolite; immediate release formulation; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 2.0 h 2.0±0.4 h PO, oral; immediate release formulation; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 2.8 h 2.8±0.8 h PO, oral; Active metabolite; immediate release formulation; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 5.5 h 5.5 h PO, oral; extended release formulation; adults; normal,healthy; The Pharmacological Basis of Therapeutics
T Max 9.0 h 9 h PO, oral; Active metabolite; extended release formulation; adults; normal,healthy; The Pharmacological Basis of Therapeutics
Tss 72.0 h 3.0 day DRUGBANK
Clearance 1.3 L/h/kg 1.3±0.6 L/h/kg Plasma clearance; DRUGBANK
Clearance 0.40 L/h/kg 0.4±0.2 L/h/kg Plasma clearance; DRUGBANK
Clearance 1.3 L/h/kg 22±10 ml/min/kg apparent clearance;  Female, women → ;Elderly → ;Hepatic cirrhosis, cirr ↓ ;RD, renal impairment, Renal disease，including uremia ↓ ; The Pharmacological Basis of Therapeutics
Clearance 0.84 L/h/kg 14 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 7.5 L/kg 7.5±3.7 L/kg DRUGBANK
Volume of Distribution 5.7 L/kg 5.7±1.8 L/kg DRUGBANK
Volume of Distribution 7.5 L/kg 7.5±3.7 L/kg Apparent volume of distribution;  Female, women → ;Elderly → ;Hepatic cirrhosis, cirr → ;RD, renal impairment, Renal disease，including uremia → ; The Pharmacological Basis of Therapeutics
Volume of Distribution 4.4 L/kg 4.4 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 5.0 h 5 h DRUGBANK
Half-life 4.9 h 4.9±2.4 h  Female, women → ;Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia ↑ ;Age → ; The Pharmacological Basis of Therapeutics
Half-life 10.3 h 10.3±54.3 h  Female, women → ;Hepatic cirrhosis, cirr ↑ ;RD, renal impairment, Renal disease，including uremia ↑ ;Age → ; The Pharmacological Basis of Therapeutics
Half-life 5.0 h 5 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 48.0 % ~48 % Urinary excretion; DRUGBANK
Eliminate Route 5.0 % 5 % Urinary excretion; Unchanged drug; DRUGBANK
Eliminate Route 4.6 % 4.6±3 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Eliminate Route 29.0 % 29±7 % Urinary excretion; Unchanged drug; The Pharmacological Basis of Therapeutics
Protein Binding 27.0 % 27±2 % plasma proteins; human, homo sapiens; DRUGBANK
Protein Binding 27.0 % 27±2 % The Pharmacological Basis of Therapeutics
Protein Binding 30.0 % 30±12 % Metabolite; The Pharmacological Basis of Therapeutics

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 112.5 mg/day 112.5 mg/day PO, oral Venlafaxine Tablets venlafaxine hydrochloride PDR
Max dose for children 150.0 mg/day 150 mg/day PO, oral Venlafaxine Tablets venlafaxine hydrochloride PDR
Max dose for children 225.0 mg/day 225 mg/day PO, oral Venlafaxine Tablets venlafaxine hydrochloride PDR
Max dose for adolescents 112.5 mg/day 112.5 mg/day PO, oral Venlafaxine Tablets venlafaxine hydrochloride PDR
Max dose for adolescents 150.0 mg/day 150 mg/day PO, oral Venlafaxine Tablets venlafaxine hydrochloride PDR
Max dose for adolescents 225.0 mg/day 225 mg/day PO, oral Venlafaxine Tablets venlafaxine hydrochloride PDR
Max dose for adults 225.0 mg/day 225 mg/day PO, oral Venlafaxine Tablets venlafaxine hydrochloride PDR
Max dose for adults 375.0 mg/day 375 mg/day PO, oral Venlafaxine Tablets venlafaxine hydrochloride PDR
Max dose for adults 225.0 mg/day 225 mg/day Venlafaxine Tablets venlafaxine hydrochloride PDR
Max dose for geriatric 225.0 mg/day 225 mg/day PO, oral Venlafaxine Tablets venlafaxine hydrochloride PDR
Max dose for geriatric 375.0 mg/day 375 mg/day PO, oral Venlafaxine Tablets venlafaxine hydrochloride PDR
Max dose for geriatric 225.0 mg/day 225 mg/day Venlafaxine Tablets venlafaxine hydrochloride PDR

Drug Property Radar Chart

...

Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1