Drug ID | DDPD00282 |
|
Drug Name | Pamidronic acid | |
Molecular Weight | 235.0695 | |
Molecular Formula | C3H11NO7P2 | |
CAS Number | 40391-99-9 | |
SMILES | NCCC(O)(P(O)(O)=O)P(O)(O)=O | |
External Links | ||
DRUGBANK | DB00282 | |
T3DB | T3D2665 | |
PubChem Compound | 4674 | |
PDR | 3305 | |
Drugs.com | Drugs.com Drug Page |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
---|---|---|---|---|---|
Melting Point | 258.0 | ℃ | 254-262 | ℃ | ChemSpider |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
---|---|---|---|---|---|---|
AUC | 10200.0 | ng.h/ml | 10.2±6.95 | ug.h/ml | normal,healthy; | DRUGBANK |
AUC | 7305.0 | ng.h/ml | 10.7-3.91 | ug.h/ml | mild renal function; | DRUGBANK |
AUC | 10100.0 | ng.h/ml | 10.1±3.38 | ug.h/ml | moderate renal function; | DRUGBANK |
AUC | 34000.0 | ng.h/ml | 34.0±8.37 | ug.h/ml | severe renal function; | DRUGBANK |
C Max | 1920.0 | ng/ml | 1.92±1.08 | ug/ml | normal,healthy; | DRUGBANK |
C Max | 1860.0 | ng/ml | 1.86±0.50 | ug/ml | mild renal function; | DRUGBANK |
C Max | 1840.0 | ng/ml | 1.84±0.58 | ug/ml | moderate renal function; | DRUGBANK |
C Max | 1930.0 | ng/ml | 1.93±0.53 | ug/ml | severe renal function; | DRUGBANK |
T Max | 4.0 | h | 4 | h | normal,healthy; | DRUGBANK |
T Max | 4.0 | h | 4 | h | mild renal function; | DRUGBANK |
T Max | 4.0 | h | 4 | h | moderate renal function; | DRUGBANK |
T Max | 4.0 | h | 4 | h | severe renal function; | DRUGBANK |
Metabolic | 0 | % | 0 | % | DRUGBANK | |
Clearance | 6.4 | L/h | 107±50 | ml/min | Average clearance; | DRUGBANK |
Clearance | 2.9 | L/h | 49±28 | ml/min | Renal clearance; | DRUGBANK |
Half-life | 28.0 | h | 28±7 | h | elimination half-life; | DRUGBANK |
Eliminate Route | 46.0 | % | 46±16 | % | Urinary excretion; | DRUGBANK |
Protein Binding | 54.0 | % | ~54 | % | DRUGBANK |
Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
---|---|---|---|---|---|---|---|---|
Max dose for adults | 90.0 | mg/dose | 90 | mg/dose | intravenous injection, IV | Pamidronate Disodium | pamidronate disodium | PDR |
Max dose for geriatric | 90.0 | mg/dose | 90 | mg/dose | intravenous injection, IV | Pamidronate Disodium | pamidronate disodium | PDR |