Basic Information

Drug ID DDPD00282 ...
Drug Name Pamidronic acid
Molecular Weight 235.0695
Molecular Formula C3H11NO7P2
CAS Number 40391-99-9
SMILES NCCC(O)(P(O)(O)=O)P(O)(O)=O
External Links
DRUGBANK DB00282
T3DB T3D2665
PubChem Compound 4674
PDR 3305
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Melting Point 258.0 254-262 ChemSpider

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
AUC 10200.0 ng.h/ml 10.2±6.95 ug.h/ml normal,healthy; DRUGBANK
AUC 7305.0 ng.h/ml 10.7-3.91 ug.h/ml mild renal function; DRUGBANK
AUC 10100.0 ng.h/ml 10.1±3.38 ug.h/ml moderate renal function; DRUGBANK
AUC 34000.0 ng.h/ml 34.0±8.37 ug.h/ml severe renal function; DRUGBANK
C Max 1920.0 ng/ml 1.92±1.08 ug/ml normal,healthy; DRUGBANK
C Max 1860.0 ng/ml 1.86±0.50 ug/ml mild renal function; DRUGBANK
C Max 1840.0 ng/ml 1.84±0.58 ug/ml moderate renal function; DRUGBANK
C Max 1930.0 ng/ml 1.93±0.53 ug/ml severe renal function; DRUGBANK
T Max 4.0 h 4 h normal,healthy; DRUGBANK
T Max 4.0 h 4 h mild renal function; DRUGBANK
T Max 4.0 h 4 h moderate renal function; DRUGBANK
T Max 4.0 h 4 h severe renal function; DRUGBANK
Metabolic 0 % 0 % DRUGBANK
Clearance 6.4 L/h 107±50 ml/min Average clearance; DRUGBANK
Clearance 2.9 L/h 49±28 ml/min Renal clearance; DRUGBANK
Half-life 28.0 h 28±7 h elimination half-life; DRUGBANK
Eliminate Route 46.0 % 46±16 % Urinary excretion; DRUGBANK
Protein Binding 54.0 % ~54 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for adults 90.0 mg/dose 90 mg/dose intravenous injection, IV Pamidronate Disodium pamidronate disodium PDR
Max dose for geriatric 90.0 mg/dose 90 mg/dose intravenous injection, IV Pamidronate Disodium pamidronate disodium PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1