Basic Information
| Drug ID | DDPD00275 |
|
| Drug Name | Olmesartan | |
| Molecular Weight | 446.5016 | |
| Molecular Formula | C24H26N6O3 | |
| CAS Number | 144689-24-7 | |
| SMILES | CCCC1=NC(=C(N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C1=NN=NN1)C(O)=O)C(C)(C)O | |
| External Links | ||
| DRUGBANK | DB00275 | |
| PubChem Compound | 158781 | |
| PDR | 2467 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.73 | - | 0.73 | - | FDA Pharmacological report |
| Boiling Point | 800.0 | ℃ | 800 | ℃ | 'MSDS' |
| Melting Point | 177.6 | ℃ | 177.6 | ℃ | 'MSDS' |
| pKa | 4.3 | - | 4.3 | - | FDA Chemical report |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| AUC | 10750.0 | ng.h/ml | 1.6-19.9 | mg.h/L | PO, oral; | DRUGBANK |
| Bioavailability | 4.5 | % | 4.5 | % | PO, oral; | DRUGBANK |
| C Max | 1160.0 | ng/ml | 0.22-2.1 | mg/L | PO, oral; | DRUGBANK |
| T Max | 2.0 | h | 1-3 | h | PO, oral; | DRUGBANK |
| Clearance | 1.3 | L/h | 1.3 | L/h | Plasma clearance; | DRUGBANK | Clearance | 0.60 | L/h | 0.6 | L/h | Renal clearance; | DRUGBANK | Clearance | 0.0174 | L/h/kg | 0.29 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 17.0 | L | 17.0 | L | DRUGBANK | |
| Half-life | 12.5 | h | 10-15 | h | elimination half-life; Oral multiple dose; | DRUGBANK | Half-life | 10.8 | h | 10.8 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 1500.0 | mg/kg | >1500 | mg/kg | dog; | DRUGBANK |
| Eliminate Route | 13.0 | % | ~10-16 | % | Urinary excretion; | DRUGBANK |
| Protein Binding | 99.0 | % | 99 | % | plasma proteins; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 40.0 | mg/day | 40 | mg/day | PO, oral | Benicar | olmesartan medoxomil | PDR |
| Max dose for children | 20.0 | mg/day | 20 | mg/day | PO, oral | Benicar | olmesartan medoxomil | PDR |
| Max dose for adolescents | 40.0 | mg/day | 40 | mg/day | PO, oral | Benicar | olmesartan medoxomil | PDR |
| Max dose for adolescents | 40.0 | mg/day | 40 | mg/day | PO, oral | Benicar | olmesartan medoxomil | PDR |
| Max dose for adolescents | 20.0 | mg/day | 20 | mg/day | PO, oral | Benicar | olmesartan medoxomil | PDR |
| Max dose for adults | 40.0 | mg/day | 40 | mg/day | PO, oral | Benicar | olmesartan medoxomil | PDR |
| Max dose for geriatric | 40.0 | mg/day | 40 | mg/day | PO, oral | Benicar | olmesartan medoxomil | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1