Basic Information
| Drug ID | DDPD00270 |
|
| Drug Name | Isradipine | |
| Molecular Weight | 371.3871 | |
| Molecular Formula | C19H21N3O5 | |
| CAS Number | 75695-93-1 | |
| SMILES | COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC2=NON=C12)C(=O)OC(C)C | |
| External Links | ||
| DRUGBANK | DB00270 | |
| PubChem Compound | 3784 | |
| PDR | 751 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 4.28 | - | 4.28 | - | SANGSTER (1994) |
| Melting Point | 169.0 | ℃ | 168-170 | ℃ | DRUGBANK |
| Water Solubility | 10.0 | mg/L | <10 | mg/L | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Absorption | 92.5 | % | 90-95 | % | DRUGBANK | |
| Bioavailability | 19.5 | % | 15-24 | % | DRUGBANK | |
| Clearance | 1.6 | L/h/kg | 26 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 1.5 | L/kg | 1.5 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 8.0 | h | 8 | h | DRUGBANK | Half-life | 3.3 | h | 3.3 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity Lethal Dose | 200.0 | mg/kg | >200 | mg/kg | PO, oral; mouse; | DRUGBANK | Toxicity Lethal Dose | 50.0 | mg/kg | ~50 | mg/kg | PO, oral; rabbit; | DRUGBANK |
| Eliminate Route | 62.5 | % | ~60-65 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 27.5 | % | 25-30 | % | Faeces excretion; | DRUGBANK |
| Protein Binding | 95.0 | % | 95 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for neonates | 0.27 | mg/kg/day | 0.27 | mg/kg/day | Isradipine | isradipine | PDR | |
| Max dose for infants | 0.27 | mg/kg/day | 0.27 | mg/kg/day | Isradipine | isradipine | PDR | |
| Max dose for children | 0.8 | mg/kg/day | 0.8 | mg/kg/day | PO, oral | Isradipine | isradipine | PDR |
| Max dose for children | 20.0 | mg/day | 20 | mg/day | PO, oral | Isradipine | isradipine | PDR |
| Max dose for adolescents | 0.8 | mg/kg/day | 0.8 | mg/kg/day | PO, oral | Isradipine | isradipine | PDR |
| Max dose for adolescents | 20.0 | mg/day | 20 | mg/day | PO, oral | Isradipine | isradipine | PDR |
| Max dose for adults | 20.0 | mg/day | 20 | mg/day | PO, oral | Isradipine | isradipine | PDR |
| Max dose for geriatric | 20.0 | mg/day | 20 | mg/day | PO, oral | Isradipine | isradipine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1