| Property Name |
Property Value |
Unit |
Raw Value |
Raw Unit |
Annotation |
Factor |
Reference |
| Bioavailability |
50.0 |
% |
45-55 |
% |
PO, oral; |
|
DRUGBANK |
Bioavailability |
100.0 |
% |
100.0 |
% |
PO, oral; extended release formulation; |
extended release formulation ↑ ; |
DRUGBANK |
Bioavailability |
55.0 |
% |
55.0 |
% |
PO, oral; Parkinson; |
|
The Pharmacological Basis of Therapeutics |
| C Max |
7.4 |
ng/ml |
7.4(2.4-13) |
ng/ml |
PO, oral; Parkinson; |
|
The Pharmacological Basis of Therapeutics |
| T Max |
1.5 |
h |
1-2 |
h |
PO, oral; |
|
DRUGBANK |
T Max |
4.0 |
h |
3.5-4.5 |
h |
PO, oral; high-fat meal; |
high-fat meal ↑ ; |
DRUGBANK |
T Max |
1.0 |
h |
1.0(0.5-6.0) |
h |
PO, oral; Parkinson; |
|
The Pharmacological Basis of Therapeutics |
| Clearance |
47.0 |
L/h |
47.0 |
L/h |
PO, oral; |
|
DRUGBANK |
Clearance |
0.67 |
L/h/kg |
11.2±5.0 |
ml/min/kg |
apparent clearance; PO, oral; Parkinson; Male, men; Female, women; patients; hydrolysis; |
Elderly ↓ ;RD, renal impairment, Renal disease，including uremia → ; |
The Pharmacological Basis of Therapeutics |
Clearance |
1.8 |
L/h/kg |
30 |
ml/min/kg |
intravenous injection, IV; human, homo sapiens; |
|
Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution |
7.5 |
L/kg |
7.5 |
L/kg |
Apparent volume of distribution; |
|
DRUGBANK |
Volume of Distribution |
7.5 |
L/kg |
7.5±2.4 |
L/kg |
Apparent volume of distribution; PO, oral; Parkinson; Male, men; Female, women; patients; hydrolysis; |
|
The Pharmacological Basis of Therapeutics |
Volume of Distribution |
7.7 |
L/kg |
7.7 |
L/kg |
intravenous injection, IV; human, homo sapiens; |
|
Human Intravenous Pharmacokinetic Dataset |
| Half-life |
6.0 |
h |
~6 |
h |
|
|
DRUGBANK |
Half-life |
6.0 |
h |
6.0 |
h |
PO, oral; |
|
The Pharmacological Basis of Therapeutics |
Half-life |
6.0 |
h |
6 |
h |
intravenous injection, IV; human, homo sapiens; |
|
Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route |
88.0 |
% |
>88 |
% |
Urinary excretion; |
|
DRUGBANK |
Eliminate Route |
10.0 |
% |
<10 |
% |
Urinary excretion; Unchanged drug; |
|
DRUGBANK |
Eliminate Route |
10.0 |
% |
<10 |
% |
Urinary excretion; Parkinson; human, homo sapiens; Unchanged drug; |
|
The Pharmacological Basis of Therapeutics |
| Protein Binding |
40.0 |
% |
40 |
% |
plasma proteins; |
|
DRUGBANK |
Protein Binding |
40.0 |
% |
~40 |
% |
Parkinson; human, homo sapiens; |
|
The Pharmacological Basis of Therapeutics |
