Basic Information
| Drug ID | DDPD00262 |
|
| Drug Name | Carmustine | |
| Molecular Weight | 214.05 | |
| Molecular Formula | C5H9Cl2N3O2 | |
| CAS Number | 154-93-8 | |
| SMILES | ClCCNC(=O)N(CCCl)N=O | |
| External Links | ||
| DRUGBANK | DB00262 | |
| T3DB | T3D4681 | |
| PubChem Compound | 2578 | |
| PDR | 142 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 1.53 | - | 1.53 | - | HANSCH,C ET AL. (1995) |
| Melting Point | 31.0 | ℃ | 31 | ℃ | PhysProp |
| Water Solubility | 4000.0 | mg/L | 4000 | mg/L | MERCK 1989) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 16.5 | % | 5-28 | % | DRUGBANK | |
| Half-life | 0.38 | h | 15-30 | min | DRUGBANK | |
| Toxicity LD50 | 20.0 | mg/kg | 20.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 45.0 | mg/kg | 45.0 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 20.0 | mg/kg | 20.0 | mg/kg | PO, oral; Rattus, Rat; | T3DB | Toxicity LD50 | 45.0 | mg/kg | 45.0 | mg/kg | PO, oral; mouse; | T3DB |
| Eliminate Route | 65.0 | % | ~60-70 | % | Urinary excretion; | DRUGBANK | Eliminate Route | 10.0 | % | ~10 | % | lung excretion; | DRUGBANK |
| Protein Binding | 80.0 | % | 80 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 200.0 | mg/m2 | 200 | mg/m2 | intravenous injection, IV; nan | q6w | Gliadel | carmustine | PDR |
| Max dose for adults | 300.0 | mg/m2 | 300 | mg/m2 | intravenous injection, IV | Gliadel | carmustine | PDR | |
| Max dose for adults | 61.6 | mg | 61.6 | mg | implanted intracranially | Gliadel | carmustine | PDR | |
| Max dose for geriatric | 200.0 | mg/m2 | 200 | mg/m2 | intravenous injection, IV; nan | q6w | Gliadel | carmustine | PDR |
| Max dose for geriatric | 300.0 | mg/m2 | 300 | mg/m2 | intravenous injection, IV | Gliadel | carmustine | PDR | |
| Max dose for geriatric | 61.6 | mg | 61.6 | mg | implanted intracranially | Gliadel | carmustine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1