Basic Information
| Drug ID | DDPD00261 |
|
| Drug Name | Anagrelide | |
| Molecular Weight | 256.088 | |
| Molecular Formula | C10H7Cl2N3O | |
| CAS Number | 68475-42-3 | |
| SMILES | ClC1=CC=C2N=C3NC(=O)CN3CC2=C1Cl | |
| External Links | ||
| DRUGBANK | DB00261 | |
| PubChem Compound | 2182 | |
| PDR | 1049 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.4 | - | 2.4 | - | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 70.0 | % | ~70 | % | PO, oral; food; | food ↑ ; | DRUGBANK |
| T Max | 1.0 | h | 1 | h | PO, oral; food; | food ↑ ; | DRUGBANK |
| Half-life | 1.5 | h | ~1.5 | h | DRUGBANK | Half-life | 2.5 | h | ~2.5 | h | DRUGBANK |
| Toxicity LD50 | 1500.0 | mg/kg | >1500 | mg/kg | PO, oral; Rattus, Rat; | DRUGBANK | Toxicity LD50 | 2500.0 | mg/kg | >2500 | mg/kg | PO, oral; mouse; | DRUGBANK |
| Eliminate Route | 1.0 | % | <1 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 2.5 | mg/dose | 2.5 | mg/dose | PO, oral | Agrylin | anagrelide hydrochloride | PDR |
| Max dose for children | 10.0 | mg/day | 10 | mg/day | PO, oral | Agrylin | anagrelide hydrochloride | PDR |
| Max dose for adolescents | 2.5 | mg/dose | 2.5 | mg/dose | PO, oral | Agrylin | anagrelide hydrochloride | PDR |
| Max dose for adolescents | 10.0 | mg/day | 10 | mg/day | PO, oral | Agrylin | anagrelide hydrochloride | PDR |
| Max dose for adults | 2.5 | mg/dose | 2.5 | mg/dose | PO, oral | Agrylin | anagrelide hydrochloride | PDR |
| Max dose for adults | 10.0 | mg/day | 10 | mg/day | PO, oral | Agrylin | anagrelide hydrochloride | PDR |
| Max dose for elderly | 2.5 | mg/dose | 2.5 | mg/dose | PO, oral | Agrylin | anagrelide hydrochloride | PDR |
| Max dose for elderly | 10.0 | mg/day | 10 | mg/day | PO, oral | Agrylin | anagrelide hydrochloride | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1