Basic Information
| Drug ID | DDPD00248 |
|
| Drug Name | Cabergoline | |
| Molecular Weight | 451.6043 | |
| Molecular Formula | C26H37N5O2 | |
| CAS Number | 81409-90-7 | |
| SMILES | [H][C@@]12CC3=CNC4=CC=CC(=C34)[C@@]1([H])C[C@H](CN2CC=C)C(=O)N(CCCN(C)C)C(=O)NCC | |
| External Links | ||
| DRUGBANK | DB00248 | |
| T3DB | T3D2727 | |
| PubChem Compound | 54746 | |
| PDR | 1447 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.6 | - | 2.6 | - | DRUGBANK |
| Melting Point | 103.0 | ℃ | 102-104 | ℃ | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Metabolic | 5.0 | % | 4-6 | % | Liver metabolism; | DRUGBANK | |
| Clearance | 0.48 | L/h | 0.008 | L/min | Renal clearance; | DRUGBANK | Clearance | 192.0 | L/h | 3.2 | L/min | Plasma clearance; | DRUGBANK |
| Half-life | 66.0 | h | 63-69 | h | elimination half-life; normal,healthy; | DRUGBANK | |
| Eliminate Route | 20.0 | % | ~20 | % | Urinary excretion; PO, oral; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 60.0 | % | ~60 | % | Faeces excretion; PO, oral; normal,healthy; human, homo sapiens; | DRUGBANK | Eliminate Route | 4.0 | % | <4 | % | Urinary excretion; PO, oral; normal,healthy; human, homo sapiens; Unchanged drug; | DRUGBANK |
| Protein Binding | 41.0 | % | 40-42 | % | plasma proteins; human, homo sapiens; | Plasma Concentration → ; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Frequency | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 1.0 | mg | 1 | mg | PO, oral | biw | Cabergoline | cabergoline | PDR |
| Max dose for geriatric | 1.0 | mg | 1 | mg | PO, oral | biw | Cabergoline | cabergoline | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1