Basic Information
| Drug ID | DDPD00242 |
|
| Drug Name | Cladribine | |
| Molecular Weight | 285.687 | |
| Molecular Formula | C10H12ClN5O3 | |
| CAS Number | 4291-63-8 | |
| SMILES | NC1=C2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C2=NC(Cl)=N1 | |
| External Links | ||
| DRUGBANK | DB00242 | |
| T3DB | T3D4774 | |
| PubChem Compound | 20279 | |
| PDR | 3604 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | -0.1 | - | -0.1 | - | DRUGBANK |
| Melting Point | 215.0 | ℃ | 215 | ℃ | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Bioavailability | 41.0 | % | 34-48 | % | PO, oral; | DRUGBANK |
| Clearance | 0.98 | L/h/kg | 978±422 | ml/h/kg | DRUGBANK | Clearance | 0.84 | L/h/kg | 14 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 4.5 | L/kg | 4.5±2.8 | L/kg | hematologic malignancies; patients; | DRUGBANK | Volume of Distribution | 9.0 | L/kg | 9.0 | L/kg | DRUGBANK | Volume of Distribution | 7.7 | L/kg | 7.7 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 5.4 | h | 5.4 | h | DRUGBANK | Half-life | 16.0 | h | 16 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Protein Binding | 20.0 | % | 20 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for adults | 0.09 | mg/kg/day | 0.09 | mg/kg/day | intravenous injection, IV | Cladribine | cladribine | PDR |
| Max dose for adults | 3.5 | mg/kg | 3.5 | mg/kg | PO, oral; in 2 years | Cladribine | cladribine | PDR |
| Max dose for geriatric | 0.09 | mg/kg/day | 0.09 | mg/kg/day | intravenous injection, IV | Cladribine | cladribine | PDR |
| Max dose for geriatric | 3.5 | mg/kg | 3.5 | mg/kg | PO, oral; in 2 years | Cladribine | cladribine | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1