Basic Information

Drug ID DDPD00241 ...
Drug Name Butalbital
Molecular Weight 224.2563
Molecular Formula C11H16N2O3
CAS Number 77-26-9
SMILES CC(C)CC1(CC=C)C(=O)NC(=O)NC1=O
External Links
DRUGBANK DB00241
PubChem Compound 2481

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 1.87 - 1.87 - Barceloux, Donald G. Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. Hoboken, N.J: John Wiley & Sons, 2012. Internet resource.
Melting Point 138.5 138.5 Barceloux, Donald G. Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. Hoboken, N.J: John Wiley & Sons, 2012. Internet resource.
Water Solubility 1700.0 mg/L 1700 mg/L Barceloux, Donald G. Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. Hoboken, N.J: John Wiley & Sons, 2012. Internet resource.

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
C Max 2100.0 ng/ml 2.1 mg/L PO, oral; DRUGBANK
T Max 2.0 h ~2 h PO, oral; DRUGBANK
Metabolic 100.0 % ~100 % Liver metabolism; DRUGBANK
Volume of Distribution 0.80 L/kg ~0.8 L/kg DRUGBANK
Half-life 35.0 h ~35 h elimination half-life; DRUGBANK
Half-life 61.0 h 61(35-88) h elimination half-life; normal,healthy; Drug combination; DRUGBANK
Toxicity TDLo 400.0 mg/kg 400.0 mg/kg PO, oral;  Female, women; DRUGBANK
Toxicity TDLo 160.0 mg/kg 160.0 mg/kg subcutaneous injection, SC; Rattus, Rat; DRUGBANK
Toxicity Lethal Dose 2000.0 mg 2.0 g adults; DRUGBANK
Eliminate Route 73.5 % 59-88 % Urinary excretion; DRUGBANK
Eliminate Route 3.6 % ~3.6 % Urinary excretion; Unchanged drug; DRUGBANK
Protein Binding 45.0 % 45 % plasma proteins; high protein binding; DRUGBANK

Maximum Dosage

Not Available

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1