Basic Information
| Drug ID | DDPD00233 |
|
| Drug Name | Aminosalicylic acid | |
| Molecular Weight | 153.1354 | |
| Molecular Formula | C7H7NO3 | |
| CAS Number | 65-49-6 | |
| SMILES | NC1=CC(O)=C(C=C1)C(O)=O | |
| External Links | ||
| DRUGBANK | DB00233 | |
| PubChem Compound | 4649 | |
| PDR | 262 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 0.89 | - | 0.89 | - | SANGSTER (1994) |
| Melting Point | 150.5 | ℃ | 150.5 | ℃ | PhysProp |
| Water Solubility | 1690.0 | mg/L | 1690 | mg/L | YALKOWSKY,SH & DANNENFELSER,RM 1992) |
| pKa | 2.05 | - | 2.05 | - | KORTUM,G ET AL (1961) |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 0.56 | L/h/kg | 9.3 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.33 | L/kg | 0.33 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 0.61 | h | 0.61 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Toxicity LD50 | 4000.0 | mg/kg | 4.0 | g/kg | PO, oral; mouse; | DRUGBANK | Toxicity LD50 | 3650.0 | mg/kg | 3650.0 | mg/kg | PO, oral; rabbit; | DRUGBANK |
| Protein Binding | 55.0 | % | 50-60 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 300.0 | mg/kg/day | 300 | mg/kg/day | PO, oral | Paser | aminosalicylic acid | PDR |
| Max dose for children | 300.0 | mg/kg/day | 300 | mg/kg/day | PO, oral | Paser | aminosalicylic acid | PDR |
| Max dose for children | 12000.0 | mg/day | 12 | g/day | PO, oral | Paser | aminosalicylic acid | PDR |
| Max dose for adolescents | 300.0 | mg/kg/day | 300 | mg/kg/day | PO, oral | Paser | aminosalicylic acid | PDR |
| Max dose for adolescents | 12000.0 | mg/day | 12 | g/day | PO, oral | Paser | aminosalicylic acid | PDR |
| Max dose for adults | 12000.0 | mg/day | 12 | g/day | PO, oral | Paser | aminosalicylic acid | PDR |
| Max dose for geriatric | 12000.0 | mg/day | 12 | g/day | PO, oral | Paser | aminosalicylic acid | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1