Basic Information
| Drug ID | DDPD00230 |
|
| Drug Name | Pregabalin | |
| Molecular Weight | 159.2261 | |
| Molecular Formula | C8H17NO2 | |
| CAS Number | 148553-50-8 | |
| SMILES | CC(C)C[C@H](CN)CC(O)=O | |
| External Links | ||
| DRUGBANK | DB00230 | |
| PubChem Compound | 5486971 | |
| PDR | 24180 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Boiling Point | 145.5 | ℃ | 144-147oC | ℃ | https://www.who.int/medicines/access/controlled-substances/PreReviewPregabalin.pdf |
| Melting Point | 177.0 | ℃ | 176-178 | ℃ | https://www.who.int/medicines/access/controlled-substances/PreReviewPregabalin.pdf |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Factor | Reference |
|---|---|---|---|---|---|---|---|
| Bioavailability | 90.0 | % | >90 | % | PO, oral; increasing doses; | increasing doses → ; | DRUGBANK |
| T Max | 1.5 | h | 1.5 | h | PO, oral; increasing dosing frequency; | increasing dosing frequency → ; | DRUGBANK | T Max | 3.0 | h | 3 | h | PO, oral; food; | food ↑ ; | DRUGBANK |
| Tss | 36.0 | h | 24-48 | h | Oral multiple dose; | DRUGBANK | |
| Metabolic | 2.0 | % | <2 | % | DRUGBANK | Metabolic | 0 | % | 0 | % | Urinary excretion; | DRUGBANK |
| Clearance | 4.4 | L/h | 67-80.9 | ml/min | Renal clearance; normal,healthy; young; | DRUGBANK | |
| Volume of Distribution | 0.50 | L/kg | ~0.5 | L/kg | Apparent volume of distribution; PO, oral; | DRUGBANK | |
| Half-life | 6.3 | h | 6.3 | h | elimination half-life; | DRUGBANK | |
| Eliminate Route | 100.0 | % | ~100 | % | Urinary excretion; | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for infants | 14.0 | mg/kg/day | 14 | mg/kg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for children | 10.0 | mg/kg/day | 10 | mg/kg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for children | 600.0 | mg/day | 600 | mg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for children | 14.0 | mg/kg/day | 14 | mg/kg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for adolescents | 600.0 | mg/day | 600 | mg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for adolescents | 10.0 | mg/kg/day | 10 | mg/kg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for adolescents | 600.0 | mg/day | 600 | mg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for adolescents | 14.0 | mg/kg/day | 14 | mg/kg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for adults | 300.0 | mg/day | 300 | mg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for adults | 600.0 | mg/day | 600 | mg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for adults | 450.0 | mg/day | 450 | mg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for adults | 330.0 | mg/day | 330 | mg/day | Tablet,PO，oral | Lyrica CR | pregabalin | PDR |
| Max dose for adults | 660.0 | mg/day | 660 | mg/day | Tablet,PO，oral | Lyrica CR | pregabalin | PDR |
| Max dose for geriatric | 300.0 | mg/day | 300 | mg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for geriatric | 600.0 | mg/day | 600 | mg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for geriatric | 450.0 | mg/day | 450 | mg/day | PO, oral | Lyrica CR | pregabalin | PDR |
| Max dose for geriatric | 330.0 | mg/day | 330 | mg/day | Tablet,PO，oral | Lyrica CR | pregabalin | PDR |
| Max dose for geriatric | 660.0 | mg/day | 660 | mg/day | Tablet,PO，oral | Lyrica CR | pregabalin | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1