Basic Information

Drug ID DDPD00224 ...
Drug Name Indinavir
Molecular Weight 613.7895
Molecular Formula C36H47N5O4
CAS Number 150378-17-9
SMILES CC(C)(C)NC(=O)[C@@H]1CN(CC2=CN=CC=C2)CCN1C[C@@H](O)C[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]1[C@H](O)CC2=CC=CC=C12
External Links
DRUGBANK DB00224
PubChem Compound 5362440
PDR 340
Drugs.com Drugs.com Drug Page

Experimental Physicochemical Property

Property Name Property Value Unit Raw Value Raw Unit Reference
Log P 2.9 - 2.9 - DRUGBANK
Melting Point 167.75 167.5-168 DRUGBANK
Water Solubility 15.0 mg/L 0.015 mg/ml DRUGBANK

Pharmacokinetic/ Toxicokinetic Property

Property Name Property Value Unit Raw Value Raw Unit Annotation Reference
Clearance 1.1 L/h/kg 18 ml/min/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Volume of Distribution 0.82 L/kg 0.82 L/kg intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Half-life 1.8 h 1.8±0.4 h DRUGBANK
Half-life 1.0 h 1 h intravenous injection, IV; human, homo sapiens; Human Intravenous Pharmacokinetic Dataset
Eliminate Route 20.0 % <20 % Urinary excretion; Unchanged drug; DRUGBANK
Protein Binding 60.0 % 60 % DRUGBANK

Maximum Dosage

Property Name Property Value Unit Raw Value Raw Unit Annotation Brand Name Component Reference
Max dose for children 2400.0 mg/day 2400 mg/day PO, oral Crixivan indinavir sulfate PDR
Max dose for adolescents 2400.0 mg/day 2400 mg/day PO, oral Crixivan indinavir sulfate PDR
Max dose for geriatric 2400.0 mg/day 2400 mg/day PO, oral Crixivan indinavir sulfate PDR

Drug Property Radar Chart

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Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1