Basic Information
| Drug ID | DDPD00224 |
|
| Drug Name | Indinavir | |
| Molecular Weight | 613.7895 | |
| Molecular Formula | C36H47N5O4 | |
| CAS Number | 150378-17-9 | |
| SMILES | CC(C)(C)NC(=O)[C@@H]1CN(CC2=CN=CC=C2)CCN1C[C@@H](O)C[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]1[C@H](O)CC2=CC=CC=C12 | |
| External Links | ||
| DRUGBANK | DB00224 | |
| PubChem Compound | 5362440 | |
| PDR | 340 | |
| Drugs.com | Drugs.com Drug Page | |
Experimental Physicochemical Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Reference |
|---|---|---|---|---|---|
| Log P | 2.9 | - | 2.9 | - | DRUGBANK |
| Melting Point | 167.75 | ℃ | 167.5-168 | ℃ | DRUGBANK |
| Water Solubility | 15.0 | mg/L | 0.015 | mg/ml | DRUGBANK |
Pharmacokinetic/ Toxicokinetic Property
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Reference |
|---|---|---|---|---|---|---|
| Clearance | 1.1 | L/h/kg | 18 | ml/min/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Volume of Distribution | 0.82 | L/kg | 0.82 | L/kg | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Half-life | 1.8 | h | 1.8±0.4 | h | DRUGBANK | Half-life | 1.0 | h | 1 | h | intravenous injection, IV; human, homo sapiens; | Human Intravenous Pharmacokinetic Dataset |
| Eliminate Route | 20.0 | % | <20 | % | Urinary excretion; Unchanged drug; | DRUGBANK |
| Protein Binding | 60.0 | % | 60 | % | DRUGBANK |
Maximum Dosage
| Property Name | Property Value | Unit | Raw Value | Raw Unit | Annotation | Brand Name | Component | Reference |
|---|---|---|---|---|---|---|---|---|
| Max dose for children | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Crixivan | indinavir sulfate | PDR |
| Max dose for adolescents | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Crixivan | indinavir sulfate | PDR |
| Max dose for geriatric | 2400.0 | mg/day | 2400 | mg/day | PO, oral | Crixivan | indinavir sulfate | PDR |
Drug Property Radar Chart
Note: Center: Q1-1.5*IQR, Edge: Q3+1.5*IQR; Q1: Quantile 1, Q3: Quantile 3, IQR: Q3-Q1